SynthesisPathology oncology research : POR2015
Meta-analysis of oncological outcome after abdominoperineal resection or low anterior resection for lower rectal cancer.
Synthesis in Pathology oncology research : POR, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Communication in decision aids for stage I-III colorectal cancer patients: a systematic review.BMJ open · 2021Pooled it
- Sphincter preservation in patients with low rectal cancer: striking the right oncological balance.Discover oncology · 2021Trial
- Comparison of morbidity and mortality of abdominoperineal resection vs low anterior resection in rectal cancer.Journal of medicine and life · 2026Article
- Review
- Minimally invasive colorectal cancer surgery: an observational study of medicare advantage and fee-for-service beneficiaries.Surgical endoscopy · 2024Observational
- Pleasurable and problematic receptive anal intercourse and diseases of the colon, rectum and anus.Nature reviews. Gastroenterology & hepatology · 2024Review
- RoboticWorld journal of gastrointestinal surgery · 2024Article
- Perioperative outcomes in male patients undergoing cystectomy, radical colorectal procedure or total pelvic exenteration.Translational andrology and urology · 2023Article
- The erectile and ejaculatory implications of the surgical management of rectal cancer.International journal of urology : official journal of the Japanese Urological Association · 2023Review
- Gluteal Propeller Perforator Flaps: A Paradigm Shift in Abdominoperineal Amputation Reconstruction.Journal of clinical medicine · 2023Article
- Analysis of Survival in Complete Pathological Response after Long-Course Chemoradiotherapy in Patients with Advanced Rectal Cancer.Current oncology (Toronto, Ont.) · 2023Article
- Surgical treatment of rectal cancer: prospective cohort study about good oncologic results and low rates of abdominoperineal excision.Revista do Colegio Brasileiro de Cirurgioes · 2023Article
- Management of primary anorectal mucosal melanoma during the COVID-19 pandemic.Ecancermedicalscience · 2023Article
- Trends of sphincter-preserving surgeries for low lying rectal cancer: A 20-year experience in China.Frontiers in oncology · 2022Article
- Distinct Prognosis of High Versus Mid/Low Rectal Cancer: a Propensity Score-Matched Cohort Study.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2019Article
- Ultralow anterior resection with implantation of gentamicin-collagen sponge and no defunctioning stoma: anastomotic leakage and local cancer relapse.Radiology and oncology · 2019Article
- Radiofrequency ablation is beneficial in simultaneous treatment of synchronous liver metastases and primary colorectal cancer.PloS one · 2018Article
- Recurrences in stage II rectal carcinoma after curative resection alone: from the viewpoint of angiogenesis.World journal of surgical oncology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In lower rectal cancer, postoperative outcome is still subject of controversy between the advocates of abdominoperineal resection (APR) and low anterior resection (LAR). Reports suggest that low anterior resection may be oncologically superior to abdominoperineal excision, although no good evidence exists to support this. Publications were identified which assessed the differences comparing 5-year survival, local recurrence, circumferential resection margin rate, complications and so on. A meta-analysis was performed to clarify the safety and feasibility of the two procedures with several types of outcome measures. A total of 13 studies met the inclusion criteria, and comprised 6,850 cases. Analysis of these data showed that LAR group was highly correlated with 5-year survival (pooled OR = 1.73, 95%CI: 1.30-2.29, P = 0.0002 random-effect). And local recurrence rate of APR group was significantly higher than that in LAR group (pooled OR = 0.63, 95%CI: 0.53-0.75, P < 0.00001 fixed-effect). Also, the circumferential resection margin (CRM) were high involved in APR group than in LAR group. (5 trials reported the data, pooled OR = 0.43, 95%CI: 0.36-0.52, P < 0.00001 fixed-effect). Besides, the incidents of overall complications of APR group was higher compared with LAR group (pooled OR = 0.52, 95%CI: 0.29-0.92, P = 0.03 random-effect). Patients treated by APR have a higher rate of CRM involvement, a higher local recurrence, and poorer prognosis than LAR. And there is evidence that in selected low rectal cancer patients, LAR can be used safely with a better oncological outcome than APR. due to the inherent limitations of the present study, for example, the trails available for this systematic review are limited and the finite retrospective data, future prospective randomized controlled trials will be useful to fully investigate these outcome measures and to confirm this conclusion.
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