ArticleScientific reports2014
Are polymorphisms of the immunoregulatory factor CD40LG implicated in acute transfusion reactions?
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 21 citations in OpenAlex.
- Two novel CD40LG gene mutations causing X-linked hyper IgM syndrome in Vietnamese patients.Clinical and experimental medicine · 2023Article
- Determining crucial genes associated with COVID-19 based on COPD FindingsComputers in biology and medicine · 2021Article
- The 3'-UTR (CA)n microsatellite on CD40LG gene as a possible genetic marker for rheumatoid arthritis in Mexican population: impact on CD40LG mRNA expression.Clinical rheumatology · 2018Article
- Duration of red blood cell storage and inflammatory marker generation.Blood transfusion = Trasfusione del sangue · 2017Review
- Levels of human platelet-derived soluble CD40 ligand depend on haplotypes of CD40LG-CD40-ITGA2.Scientific reports · 2016Article
- Improving platelet transfusion safety: biomedical and technical considerations.Blood transfusion = Trasfusione del sangue · 2016Review
- Transfusion as an Inflammation Hit: Knowns and Unknowns.Frontiers in immunology · 2016Review
- Editorial: Platelets as Immune Cells in Physiology and Immunopathology.Frontiers in immunology · 2015Article
- Pilot study of ABO-isogroup or universal plasma pools with or without pathogen reduction treatment.Blood transfusion = Trasfusione del sangueArticle
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The CD40 ligand (CD40L/CD154), a member of TNF superfamily, is notably expressed on activated CD4+ T-cells and stimulated platelets. CD40L is linked to a variety of pathologies and to acute transfusion reactions (ATR). Mutations in this gene (CD40LG) lead to X-linked hyper-IgM syndrome. Some CD40LG polymorphisms are associated with variable protein expression. The rationale behind this study is that CD40L protein has been observed to be involved in ATR. We wondered whether genetic polymorphisms are implicated. We investigated genetic diversity in the CD40LG using DHPLC and capillary electrophoresis for screening and genotyping (n = 485 French and Tunisian blood donors). We identified significant difference in the CD40LG linkage pattern between the two populations. Variant minor alleles were significantly over-represented in Tunisian donors (P<0.0001 to 0.0270). We found higher heterogeneity in the Tunisian, including three novel low frequency variants. As there was not a particular pattern of CD40LG in single apheresis donors whose platelet components induced an ATR, we discuss how this information may be useful for future disease association studies on CD40LG.
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