ArticleActa ophthalmologica2015
Conjunctival microvascular haemodynamics in sickle cell retinopathy.
Article in Acta ophthalmologica, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Conjunctival Venular Hemodynamic Biomarkers in Glaucoma.Translational vision science & technology · 2025Article
- Preferential Sites of Retinal Capillary Occlusion in Sickle Cell Disease.Investigative ophthalmology & visual science · 2025Article
- A High-Fidelity Computational Model for Predicting Blood Cell Trafficking and 3D Capillary Hemodynamics in Retinal Microvascular Networks.Investigative ophthalmology & visual science · 2024Article
- Conjunctival optical coherence tomography angiography imaging in sickle cell maculopathy.American journal of ophthalmology case reports · 2022Article
- Foveal avascular zone morphology and parafoveal capillary perfusion in sickle cell retinopathy.The British journal of ophthalmology · 2020Article
- Functional slit lamp biomicroscopy metrics correlate with cardiovascular risk.The ocular surface · 2019Article
- Factors Affecting Microvascular Responses in the Bulbar Conjunctiva in Habitual Contact Lens Wearers.Investigative ophthalmology & visual science · 2018Article
- Inter-visit variability of conjunctival microvascular hemodynamic measurements in healthy and diabetic retinopathy subjects.Microvascular research · 2018Article
- A microfluidic platform to study the effects of vascular architecture and oxygen gradients on sickle blood flow.Microcirculation (New York, N.Y. : 1994) · 2017Review
- Automated Real-Time Conjunctival Microvasculature Image Stabilization.IEEE transactions on medical imaging · 2016Article
- Automated Assessment of Hemodynamics in the Conjunctival Microvasculature Network.IEEE transactions on medical imaging · 2016Article
- Conjunctival and pulmonary hemodynamic properties in sickle cell disease subjects with and without pulmonary hypertension.Clinical case reports · 2015Article
- Feasibility of assessment of conjunctival microvascular hemodynamics in unilateral ischemic stroke.Microvascular research · 2015Article
- Changes in Conjunctival Hemodynamics Predict Albuminuria in Sickle Cell Nephropathy.American journal of nephrology · 2015Article
- Do the Eyes Reveal More Than Scleral Icterus in Sickle Cell Disease?American journal of nephrology · 2015Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTo determine alterations in bulbar conjunctival microvascular haemodynamics in sickle cell retinopathy (SCR) subjects with focal macular thinning (FMT).
methodsConjunctival microcirculation imaging and spectral domain optical coherence tomography (SD-OCT) were performed in 22 subjects (eyes) diagnosed with SCR. Based on evaluation of SD-OCT retinal thickness maps, eyes were assigned to one of the two groups: with or without FMT. Conjunctival venular diameter and axial blood velocity were measured in multiple venules in each eye by customized image analysis algorithms. Measurements were then categorized into two vessel size groups (vessel size 1 and 2) and compared between FMT groups. A Pearson correlation coefficient was computed to assess the relationship between retinal thickness and axial blood velocity.
resultsMean age, haematocrit, sickle cell haemoglobin type and median retinopathy score were not significantly different between the two groups (p ≥ 0.1). Retinal thickness in parafoveal and perifoveal temporal subfields was significantly lower in eyes with FMT as compared to eyes without FMT (p ≤ 0.04). There was a significant effect of FMT on axial blood velocity (p = 0.04), while the effect of vessel size was not significant (p = 0.4). In vessel size 1, axial blood velocity was lower in eyes with FMT than in eyes without FMT (p = 0.03), while in vessel size 2, there was no statistically significant difference between FMT groups (p = 0.1). In vessel size 1, there was a significant positive correlation between axial blood velocity and retinal thickness in the perifoveal (r = 0.48, p = 0.02) and parafoveal (r = 0.43, p = 0.04) temporal subfields.
conclusionConjunctival axial blood velocity in small venules is reduced in SCR subjects with focal macular thinning.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.