ArticleBiomechanics and modeling in mechanobiology2015
A coupled model of neovessel growth and matrix mechanics describes and predicts angiogenesis in vitro.
Article in Biomechanics and modeling in mechanobiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Simulation of Soluble and Bound VEGF-stimulated in vitro Capillary-like Network Formation on Deformed Substrate.PLoS computational biology · 2024Article
- Article
- Modeling the extracellular matrix in cell migration and morphogenesis: a guide for the curious biologist.Frontiers in cell and developmental biology · 2024Review
- A Comprehensive Look at In Vitro Angiogenesis Image Analysis Software.International journal of molecular sciences · 2023Review
- External mechanical loading overrules cell-cell mechanical communication in sprouting angiogenesis during early bone regeneration.PLoS computational biology · 2023Article
- Spatial Configurations of 3D Extracellular Matrix Collagen Density and Anisotropy Simultaneously Guide Angiogenesis.PLoS computational biology · 2023Article
- On the role of mechanical signals on sprouting angiogenesis through computer modeling approaches.Biomechanics and modeling in mechanobiology · 2022Review
- Microenvironmental modulation of the developing tumour: an immune-stromal dialogue.Molecular oncology · 2021Review
- On the preservation of vessel bifurcations during flow-mediated angiogenic remodelling.PLoS computational biology · 2021Article
- Scaffold Architecture and Matrix Strain Modulate Mesenchymal Cell and Microvascular Growth and Development in a Time Dependent Manner.Cellular and molecular bioengineering · 2020Article
- Extracellular matrix compression temporally regulates microvascular angiogenesis.Science advances · 2020Article
- Stromal Cells Promote Neovascular Invasion Across Tissue Interfaces.Frontiers in physiology · 2020Article
- The extracellular matrix in tumor progression and metastasis.Clinical & experimental metastasis · 2019Review
- A Plugin Framework for Extending the Simulation Capabilities of FEBio.Biophysical journal · 2018Article
- Cellular Microbiaxial Stretching to Measure a Single-Cell Strain Energy Density Function.Journal of biomechanical engineering · 2017Article
- FEBio: History and Advances.Annual review of biomedical engineering · 2017Review
- A Validated Multiscale In-Silico Model for Mechano-sensitive Tumour Angiogenesis and Growth.PLoS computational biology · 2017Article
- In Silico Investigation of Angiogenesis with Growth and Stress Generation Coupled to Local Extracellular Matrix Density.Annals of biomedical engineering · 2015Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
During angiogenesis, sprouting microvessels interact with the extracellular matrix (ECM) by degrading and reorganizing the matrix, applying traction forces, and producing deformation. Morphometric features of the resulting microvascular network are affected by the interaction between the matrix and angiogenic microvessels. The objective of this study was to develop a continuous-discrete modeling approach to simulate mechanical interactions between growing neovessels and the deformation of the matrix in vitro. This was accomplished by coupling an existing angiogenesis growth model which uses properties of the ECM to regulate angiogenic growth with the nonlinear finite element software FEBio (www.febio.org). FEBio solves for the deformation and remodeling of the matrix caused by active stress generated by neovessel sprouts, and this deformation was used to update the ECM into the current configuration. After mesh resolution and parameter sensitivity studies, the model was used to accurately predict vascular alignment for various matrix boundary conditions. Alignment primarily arises passively as microvessels convect with the deformation of the matrix, but active alignment along collagen fibrils plays a role as well. Predictions of alignment were most sensitive to the range over which active stresses were applied and the viscoelastic time constant in the material model. The computational framework provides a flexible platform for interpreting in vitro investigations of vessel-matrix interactions, predicting new experiments, and simulating conditions that are outside current experimental capabilities.
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