ArticleMolecules (Basel, Switzerland)2014
Synthesis, anticancer and antibacterial activity of salinomycin N-benzyl amides.
Article in Molecules (Basel, Switzerland), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
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- Massively parallel combination screen reveals small molecule sensitization of antibiotic-resistant Gram-negative ESKAPE pathogens.bioRxiv : the preprint server for biology · 2024Article
- Prenylated Flavonoids with Selective Toxicity against Human Cancers.International journal of molecular sciences · 2023Article
- Synthesis of FunctionalizedPharmaceuticals (Basel, Switzerland) · 2022Article
- DIPEA-induced activation of OHRSC advances · 2022Article
- Salinomycin as a potent anticancer stem cell agent: State of the art and future directions.Medicinal research reviews · 2022Review
- A Docosahexaenoic Acid Derivative (Molecules (Basel, Switzerland) · 2022Article
- Identification of Antimicrobial Compounds in TwoFrontiers in microbiology · 2022Article
- Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2021Article
- Salinomycin-Based Drug Delivery Systems: Overcoming the Hurdles in Cancer Therapy.Pharmaceutics · 2021Review
- Repurposing Screens of FDA-Approved Drugs Identify 29 Inhibitors of SARS-CoV-2.Journal of microbiology and biotechnology · 2020Article
- Primary Human Hepatocytes, but Not HepG2 or Balb/c 3T3 Cells, Efficiently Metabolize Salinomycin and Are Resistant to Its Cytotoxicity.Molecules (Basel, Switzerland) · 2020Article
- Polymeric Micellar Formulation Enhances Antimicrobial and Anticancer Properties of Salinomycin.Pharmaceutical research · 2019Article
- Grafting of multiwalled carbon nanotubes with pyrazole derivatives: characterization, antimicrobial activity and molecular docking study.International journal of nanomedicine · 2019Article
- Evaluating a Variable Porosity Wound Dressing With Anti-Scar Properties in a Porcine Model of Wound Healing.Eplasty · 2018Article
- Trypanosoma brucei: trypanocidal and cell swelling activities of lasalocid acid.Parasitology research · 2017Article
- Salinomycin Hydroxamic Acids: Synthesis, Structure, and Biological Activity of Polyether Ionophore Hybrids.ACS medicinal chemistry letters · 2016Article
- Discovery of a (19)F MRI sensitive salinomycin derivative with high cytotoxicity towards cancer cells.Chemical communications (Cambridge, England) · 2016Article
- Design, Synthesis, DFT Study and Antifungal Activity of Pyrazolecarboxamide Derivatives.Molecules (Basel, Switzerland) · 2016Article
Corrections and comments
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Authors and funding
9 authors.
Funding
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Abstract
A series of 12 novel monosubstituted N-benzyl amides of salinomycin (SAL) was synthesized for the first time and characterized by NMR and FT-IR spectroscopic methods. Molecular structures of three salinomycin derivatives in the solid state were determined using single crystal X-ray method. All compounds obtained were screened for their antiproliferative activity against various human cancer cell lines as well as against the most problematic bacteria strains such as methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus epidermidis (MRSE), and Mycobacterium tuberculosis. Novel salinomycin derivatives exhibited potent anticancer activity against drug-resistant cell lines. Additionally, two N-benzyl amides of salinomycin revealed interesting antibacterial activity. The most active were N-benzyl amides of SAL substituted at -ortho position and the least anticancer active derivatives were those substituted at the -para position.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.