ArticleProceedings of the National Academy of Sciences of the United States of America1989
Endothelin activates the dihydropyridine-sensitive, voltage-dependent Ca2+ channel in vascular smooth muscle.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
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Who cites it
67 citing papers in PubMed, 351 citations in OpenAlex.
- Impaired acetylcholine-induced cutaneous vasodilation in young smokers: roles of nitric oxide and prostanoids.American journal of physiology. Heart and circulatory physiology · 2013Trial
- Evolutionary Unmasking Resuscitative Therapeutics Potential of Centhaquin Citrate in Hypovolemic Shock.CNS & neurological disorders drug targets · 2024Review
- Article
- Characterisation of preproendothelin-1 derived peptides identifies Endothelin-Like Domain Peptide as a modulator of Endothelin-1.Scientific reports · 2017Article
- Smooth Muscle Ion Channels and Regulation of Vascular Tone in Resistance Arteries and Arterioles.Comprehensive Physiology · 2017Review
- Regulation of Coronary Blood Flow.Comprehensive Physiology · 2017Review
- Endothelin Receptors, Mitochondria and Neurogenesis in Cerebral Ischemia.Current neuropharmacology · 2016Review
- Functional expression of smooth muscle-specific ion channels in TGF-β(1)-treated human adipose-derived mesenchymal stem cells.American journal of physiology. Cell physiology · 2013Article
- Kinase-dependent activation of voltage-gated Ca2+ channels by ET-1 in pulmonary arterial myocytes during chronic hypoxia.American journal of physiology. Lung cellular and molecular physiology · 2012Article
- Trypanosoma cruzi invades host cells through the activation of endothelin and bradykinin receptors: a converging pathway leading to chagasic vasculopathy.British journal of pharmacology · 2012Article
- Hypoxic pulmonary vasoconstriction.Physiological reviews · 2012Review
- Endothelin antagonism in portal hypertensive mice: implications for endothelin receptor-specific signaling in liver disease.American journal of physiology. Gastrointestinal and liver physiology · 2009Article
- Metabotropic Ca(2+) channel-induced Ca(2+) release and ATP-dependent facilitation of arterial myocyte contraction.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Pharmacological reversal of endothelin-1 mediated constriction of the spiral modiolar artery: a potential new treatment for sudden sensorineural hearing loss.BMC ear, nose, and throat disorders · 2005Article
- Extracellular Mg(2+) blocks endothelin-1-induced contraction through the inhibition of non-selective cation channels in coronary smooth muscle.Pflugers Archiv : European journal of physiology · 2004Article
- ET-1-associated vasomotion and vasospasm in lymphatic vessels of the guinea-pig mesentery.British journal of pharmacology · 2003Article
- Mechanical and electrophysiological effects of endothelin-1 on guinea-pig isolated lower oesophageal sphincter circular smooth muscle.British journal of pharmacology · 2002Article
- Effects of potassium channel opener KRN4884 on human conduit arteries used as coronary bypass grafts.British journal of clinical pharmacology · 2000Article
- Electrophysiological effects of endothelin-1 and their relationship to contraction in rat renal arterial smooth muscle.British journal of pharmacology · 2000Article
- Insights into pathogenesis and treatment of cytokines in cardiomyopathy.Current cardiology reports · 2000Review
7 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endothelin is a potent endothelium-derived vasoconstrictor peptide recently characterized from porcine and human vascular endothelial cells. Here we provide evidence that endothelin activates the dihydropyridine-sensitive, voltage-dependent Ca2+ channel in porcine coronary artery smooth muscle. The vasoconstrictor action of endothelin is efficiently antagonized by low doses of the dihydropyridine Ca2+-channel blocker nicardipine. Endothelin augments the Ca2+-induced contraction in a high-K+ depolarizing solution, markedly enhances high-threshold Ca2+-channel current on the whole-cell patch clamp recording, and causes a sustained increase in the intracellular Ca2+ that is largely dependent on extracellular Ca2+. These findings suggest that endothelin exerts its vasoconstrictor effect by either directly or indirectly activating the voltage-dependent Ca2+ channel.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.