Evidence map›Paper›PMID 25429520›Full record

ArticleNature communications2014

FGF signalling restricts haematopoietic stem cell specification via modulation of the BMP pathway.

Claire Pouget, Tessa Peterkin, Filipa Costa Simões, Yoonsung Lee, David Traver, Roger Patient

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 57 citations in OpenAlex.

  1. Gpr171 regulates embryonic hematopoietic stem cell emergence via ERK1/2 and Notch signaling.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. The evolving hematopoietic niche during development.Frontiers in molecular biosciences · 2024
    Review
  7. Review
  8. Article
  9. Learning from Zebrafish Hematopoiesis.Advances in experimental medicine and biology · 2023
    Review
  10. Review
  11. Review
  12. TRIM44 Promotes Endometrial Carcinoma Progression by Activating the FRS2 Signalling Pathway.Evidence-based complementary and alternative medicine : eCAM · 2022
    Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Claire Pouget1] Department of Cellular and Molecular Medicine, Section of Cell and Developmental Biology, University of California, La Jolla, San Diego, California 92093, USA [2] MRC Molecular Hematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX1 9DS, UK.
Tessa PeterkinMRC Molecular Hematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX1 9DS, UK.
Filipa Costa SimõesMRC Molecular Hematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX1 9DS, UK.
Yoonsung LeeDepartment of Cellular and Molecular Medicine, Section of Cell and Developmental Biology, University of California, La Jolla, San Diego, California 92093, USA.
David TraverDepartment of Cellular and Molecular Medicine, Section of Cell and Developmental Biology, University of California, La Jolla, San Diego, California 92093, USA.
Roger PatientMRC Molecular Hematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX1 9DS, UK.
MRC Weatherall Institute of Molecular Medicine · GBUniversity of California, San Diego · US

Funding

FGF signaling in the specification and emergence of hematopoietic stem cellsR01HL119056 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TRAVER, DAVID · 2014 to 2017
$1.5M
Medical Research Council MC_U137981013Medical Research Council MC_UU_12009/8NHLBI NIH HHS R01 HL119056
6 · The paper itself

Abstract

Haematopoietic stem cells (HSCs) are produced during embryogenesis from the floor of the dorsal aorta. The localization of HSCs is dependent on the presence of instructive signals on the ventral side of the vessel. The nature of the extrinsic molecular signals that control the aortic haematopoietic niche is currently poorly understood. Here we demonstrate a novel requirement for FGF signalling in the specification of aortic haemogenic endothelium. Our results demonstrate that FGF signalling normally acts to repress BMP activity in the subaortic mesenchyme through transcriptional inhibition of bmp4, as well as through activation of two BMP antagonists, noggin2 and gremlin1a. Taken together, these findings demonstrate a key role for FGF signalling in establishment of the developmental HSC niche via its regulation of BMP activity in the subaortic mesenchyme. These results should help inform strategies to recapitulate the development of HSCs in vitro from pluripotent precursors.

Indexed as

Cell DifferentiationAnimalsAortaBone Morphogenetic Protein 4Carrier ProteinsEndothelium, VascularFibroblast Growth FactorsGene Expression Regulation, DevelopmentalHematopoietic Stem CellsMesodermSignal TransductionStem Cell NicheVascular Endothelial Growth Factor AZebrafishZebrafish Proteinsbmp4 protein, zebrafishBone Morphogenetic Protein 4Carrier ProteinsFibroblast Growth Factorsgrem1a protein, zebrafishVascular Endothelial Growth Factor AZebrafish Proteins

Identifiers

PMID25429520
PMCPMC4374634
OpenAlexW1968053686

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.