ArticleProceedings of the National Academy of Sciences of the United States of America1989
Parvalbumin increases in the caudate putamen of rats with vitamin D hypervitaminosis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 98 citations in OpenAlex.
- Associations of vitamin D receptor polymorphisms with risk of Alzheimer's disease, Parkinson's disease, and mild cognitive impairment: a systematic review and meta-analysis.Frontiers in aging neuroscience · 2024Pooled it
- The Role of Vitamin D in Neuropathic Pain: Biological Mechanisms and Clinical Relevance.International journal of molecular sciences · 2026Review
- Vitamin D-Mediated Immunoregulation in Degenerative Diseases: Insights into Cardiovascular, Neurodegenerative and Musculoskeletal Disorders.Nutrients · 2026Review
- Night shift work, poor sleep quality and unhealthy sleep behaviors are positively associated with the risk of epilepsy disease.BMC public health · 2024Article
- Optimization of Transcardiac Perfusion for More Accurately Evaluating Biodistribution of Large Molecules.International journal of molecular sciences · 2024Article
- "You are my sunshine, my only sunshine": maternal vitamin D status and supplementation in pregnancy and their effect on neonatal and childhood outcomes.Hormones (Athens, Greece) · 2023Review
- Vitamin D and neurodegenerative diseases.Heliyon · 2023Review
- Vitamin D and Parkinson's Disease.Nutrients · 2022Review
- Can Brain Health Be Supported by Vitamin D-Based Supplements? A Critical Review.Brain sciences · 2020Review
- The Molecular Mechanisms by Which Vitamin D Prevents Insulin Resistance and Associated Disorders.International journal of molecular sciences · 2020Review
- Neonatal vitamin D levels and cognitive ability in young adulthood.European journal of nutrition · 2020Article
- Review
- Vitamin D and Neurological Diseases: An Endocrine View.International journal of molecular sciences · 2017Review
- Reduced ability of calcitriol to promote augmented dopamine release in the lesioned striatum of aged rats.Neurochemistry international · 2017Article
- Vitamin D receptor gene polymorphisms and cognitive decline in Parkinson's disease.Journal of the neurological sciences · 2016Article
- Vitamin D Levels and the Risk of Cognitive Decline in Chinese Elderly People: the Chinese Longitudinal Healthy Longevity Survey.The journals of gerontology. Series A, Biological sciences and medical sciences · 2016Article
- Vitamin D interacts with Esr1 and Igf1 to regulate molecular pathways relevant to Alzheimer's disease.Molecular neurodegeneration · 2016Article
- Calcitriol promotes augmented dopamine release in the lesioned striatum of 6-hydroxydopamine treated rats.Neurochemical research · 2014Article
- Vitamin D as a potential therapy in amyotrophic lateral sclerosis.CNS neuroscience & therapeutics · 2014Review
- Roles of vitamin D in amyotrophic lateral sclerosis: possible genetic and cellular signaling mechanisms.Molecular brain · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The influence of chronic vitamin D3 application on the concentration of the four calcium-binding proteins parvalbumin, the 28-kDa calbindin-D, calmodulin, and S-100 was studied in various brain regions and in the kidney. Young rats were administered daily 20,000 international units of vitamin D3 per kg (body weight) over a period of 4 months. This chronic treatment resulted in a clinically mild hypervitaminosis that did not affect the content of calmodulin, the 28-kDa calbindin-D, and S-100. Also the concentration of parvalbumin in the cerebral cortex, hippocampus, and kidney remained unchanged. On the other hand, parvalbumin was increased about 50% in the caudate putamen of hypervitaminotic animals as compared to controls. Our results indicate that the metabolism of parvalbumin in the caudate putamen can be influenced by variations of the blood level of this steroid hormone.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.