ArticleProceedings of the National Academy of Sciences of the United States of America1989
Calcium channel activity of purified human synexin and structure of the human synexin gene.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 152 citations in OpenAlex.
- Role of annexin A7 in the occurrence and progression of coronary atherosclerosis: a narrative review.Cardiovascular diagnosis and therapy · 2025Review
- A Dominant-Negative Mutant of ANXA7 Impairs Calcium Signaling and Enhances the Proliferation of Prostate Cancer Cells by Downregulating the IP3 Receptor and the PI3K/mTOR Pathway.International journal of molecular sciences · 2023Article
- Annexin A protein family: Focusing on the occurrence, progression and treatment of cancer.Frontiers in cell and developmental biology · 2023Review
- Structure of the ALS Mutation Target Annexin A11 Reveals a Stabilising N-Terminal Segment.Biomolecules · 2020Article
- Expression of Metazoan Annexins in Yeast Provides Protection Against Deleterious Effects of the Biofuel Isobutanol.Scientific reports · 2019Article
- Annexins induce curvature on free-edge membranes displaying distinct morphologies.Scientific reports · 2018Article
- Lineage-specific splicing of a brain-enriched alternative exon promotes glioblastoma progression.The Journal of clinical investigation · 2014Article
- Annexin A7 trafficking to alveolar type II cell surface: possible roles for protein insertion into membranes and lamellar body secretion.Biochimica et biophysica acta · 2013Article
- Secretagogues of lung surfactant increase annexin A7 localization with ABCA3 in alveolar type II cells.Biochimica et biophysica acta · 2011Article
- Cluster analysis and phylogenetic relationship in biomarker identification of type 2 diabetes and nephropathy.International journal of diabetes in developing countries · 2010Article
- Novel protein ligands of the annexin A7 N-terminal region suggest pro-beta helices engage one another with high specificity.General physiology and biophysics · 2009Article
- Loss of the F-actin binding and vesicle-associated protein comitin leads to a phagocytosis defect.Eukaryotic cell · 2002Article
- Proteolytic signals in the primary structure of annexins.Molecular and cellular biochemistry · 2002Article
- Annexin VII as a novel marker for invasive phenotype of malignant melanoma.Japanese journal of cancer research : Gann · 2000Article
- Expression and localisation of annexin VII (synexin) isoforms in differentiating myoblasts.Journal of muscle research and cell motility · 1999Article
- Membrane fusion protein synexin (annexin VII) as a Ca2+/GTP sensor in exocytotic secretion.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Novel isoforms of synexin in Xenopus laevis: multiple tandem PGQM repeats distinguish mRNAs in specific adult tissues and embryonic stages.The Biochemical journal · 1996Article
- Linking microfilaments to intracellular membranes: the actin-binding and vesicle-associated protein comitin exhibits a mannose-specific lectin activity.The EMBO journal · 1996Article
- Identification, localization, and functional implications of an abundant nematode annexin.The Journal of cell biology · 1996Article
- Expression and characterization of a Dictyostelium discoideum annexin.Molecular and cellular biochemistry · 1994Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synexin is a calcium-dependent membrane binding protein that not only fuses membranes but also acts as a voltage-dependent calcium channel. We have isolated and sequenced a set of overlapping cDNA clones for human synexin. The derived amino acid sequence of synexin reveals strong homology in the C-terminal domain with a previously identified class of calcium-dependent membrane binding proteins. These include endonexin II, lipocortin I, calpactin I heavy chain (p36), protein II, and calelectrin 67K. The Mr 51,000 synexin molecule can be divided into a unique, highly hydrophobic N-terminal domain of 167 amino acids and a conserved C-terminal region of 299 amino acids. The latter domain is composed of alternating hydrophobic and hydrophilic segments. Analysis of the entire structure reveals possible insights into such diverse properties as voltage-sensitive calcium channel activity, ion selectivity, affinity for phospholipids, and membrane fusion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.