ArticlePloS one2014
Proteomic analysis of highly prevalent amyloid A amyloidosis endemic to endangered island foxes.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Article
- Identification and characterization of spontaneous AA amyloidosis in CD-1 mice used in toxicity studies: implications of SAA1 and SAA2 copy number variations.Journal of toxicologic pathology · 2025Article
- Surveillance of amyloidosis in stranded and bycaught cetaceans off Hokkaido, Japan.The Journal of veterinary medical science · 2019Article
- Conservation of the Amyloid Interactome Across Diverse Fibrillar Structures.Scientific reports · 2019Article
- Accelerated pre-senile systemic amyloidosis in PACAP knockout mice - a protective role of PACAP in age-related degenerative processes.The Journal of pathology · 2018Article
- Noncerebral Amyloidoses: Aspects on Seeding, Cross-Seeding, and Transmission.Cold Spring Harbor perspectives in medicine · 2018Review
- Systemic AA amyloidosis in the red fox (Vulpes vulpes).Protein science : a publication of the Protein Society · 2017Article
- Longitudinal study of experimental induction of AA amyloidosis in mice seeded with homologous and heterologous AA fibrils.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2016Article
- Systemic Amyloid A Amyloidosis in Island Foxes (Urocyon littoralis): Severity and Risk Factors.Veterinary pathology · 2016Article
- Polymorphism of Amyloid Fibrils In Vivo.Angewandte Chemie (International ed. in English) · 2016Article
- Renal amyloid-A amyloidosis in cats: Characterization of proteinuria and biomarker discovery, and associations with kidney histology.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Amyloid A (AA) amyloidosis is a debilitating, often fatal, systemic amyloid disease associated with chronic inflammation and persistently elevated serum amyloid A (SAA). Elevated SAA is necessary but not sufficient to cause disease and the risk factors for AA amyloidosis remain poorly understood. Here we identify an extraordinarily high prevalence of AA amyloidosis (34%) in a genetically isolated population of island foxes (Urocyon littoralis) with concurrent chronic inflammatory diseases. Amyloid deposits were most common in kidney (76%), spleen (58%), oral cavity (45%), and vasculature (44%) and were composed of unbranching, 10 nm in diameter fibrils. Peptide sequencing by mass spectrometry revealed that SAA peptides were dominant in amyloid-laden kidney, together with high levels of apolipoprotein E, apolipoprotein A-IV, fibrinogen-α chain, and complement C3 and C4 (false discovery rate ≤ 0.05). Reassembled peptide sequences showed island fox SAA as an 111 amino acid protein, most similar to dog and artic fox, with 5 unique amino acid variants among carnivores. SAA peptides extended to the last two C-terminal amino acids in 5 of 9 samples, indicating that near full length SAA was often present in amyloid aggregates. These studies define a remarkably prevalent AA amyloidosis in island foxes with widespread systemic amyloid deposition, a unique SAA sequence, and the co-occurrence of AA with apolipoproteins.
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