Observational studyJournal of perinatology : official journal of the California Perinatal Association2015
Assessment of pain during application of nasal-continuous positive airway pressure and heated, humidified high-flow nasal cannulae in preterm infants.
Observational study in Journal of perinatology : official journal of the California Perinatal Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- High Flow Nasal Cannula for Weaning Nasal Continuous Positive Airway Pressure in Preterm Infants: A Systematic Review and Meta-Analysis.Neonatology · 2024Pooled it
- High flow nasal cannula for respiratory support in preterm infants.The Cochrane database of systematic reviews · 2016Pooled it
- Trial
- Early successful weaning from continuous positive airway pressure in infants <32 weeks of gestation: predictors of success.Frontiers in pediatrics · 2025Article
- Evaluating Pressure Variability and Influencing Factors during High-Flow Nasal Cannula Therapy in Premature Infants.Children (Basel, Switzerland) · 2024Article
- Biomarkers for assessing pain and pain relief in the neonatal intensive care unit.Frontiers in pain research (Lausanne, Switzerland) · 2024Review
- The effect of the swaddling method on stress levels in newborns administered nasal CPAP.BMC pediatrics · 2023Article
- Nasal high flow therapy for primary respiratory support in preterm infants.The Cochrane database of systematic reviews · 2023Review
- Article
- Recent advances in the use of high flow nasal oxygen therapies.Frontiers in medicine · 2022Review
- Article
- The Comparison of HHHFNC and NCPAP in Extremely Low-Birth-Weight Preterm Infants After Extubation: A Single-Center Randomized Controlled Trial.Frontiers in pediatrics · 2020Article
- Predicting Lung Health Trajectories for Survivors of Preterm Birth.Frontiers in pediatrics · 2020Review
- Article
- Nasal high flow therapy in very low birth weight infants with mild respiratory distress syndrome: a single center experience.Italian journal of pediatrics · 2017Article
- A Strategy to Reduce Critical Cardiorespiratory Alarms due to Intermittent Enteral Feeding of Preterm Neonates in Intensive Care.Interactive journal of medical research · 2017Article
- Consensus approach to nasal high-flow therapy in neonates.Journal of perinatology : official journal of the California Perinatal Association · 2017Article
- Article
- Nasal high flow treatment in preterm infants.Maternal health, neonatology and perinatology · 2017Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess pain and compare its severity in preterm infants during application of nasal-continuous positive airway pressure (nCPAP) and heated, humidified high-flow nasal cannulae (HHHFNC). STUDY
designAn observational cross-sectional study. Sixty preterm infants, categorized into nCPAP (n=37) and HHHFNC groups (n=23). Pain response was assessed using Premature Infant Pain Profile (PIPP), duration of first cry and salivary-cortisol concentrations.
resultThe PIPP scores were significantly higher in the nCPAP compared with HHHFNC group (10 (7-12) vs 4 (2-6), P<0.01). None of the infants in the HHHFNC group had severe pain defined as a PIPP score >12, compared with 5 (13.5%) infants in the nCPAP group. Salivary-cortisol concentrations were significantly higher in nCPAP group compared with the HHHFNC group (5.0 (3.6-5.9) vs 1.6 (1.0-2.3) nmol l(-1), P<0.01). A lower incidence of cry was observed for infants in the HHHFNC group compared with the nCPAP group (11 (47.8%) vs 30 (81.1%), P<0.001), however, the duration of first cry was not significantly different between groups. The respiratory rate was significantly lower after application of HHHFNC compared with nCPAP (P<0.001). There were no significant differences between groups with regard to fraction of inspired oxygen (FiO2), oxygen saturation by pulse oximeter (SpO2) and heart rate.
conclusionThe application of HHHFNC in preterm infants is associated with less pain compared with nCPAP, as it is associated with less PIPP scores and lower salivary-cortisol concentrations.
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