Evidence map›Paper›PMID 25429358›Full record

ArticleTranslational cancer research2013

Gold nanoparticles in radiation research: potential applications for imaging and radiosensitization.

Jay F Dorsey, Lova Sun, Daniel Y Joh, Alon Witztum, Gary D Kao, Michelle Alonso-Basanta, Stephen Avery, Stephen M Hahn, Ajlan Al Zaki, Andrew Tsourkas

Abstract read
In one paragraph

Article in Translational cancer research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed.

  1. Article
  2. Luminescent protein-gold compounds for nanomedicine.Nanomedicine (London, England) · 2025
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Effect of detector placement on joint estimation in X-ray fluorescence emission tomography.IEEE transactions on radiation and plasma medical sciences · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Joint Estimation of Metal Density and Attenuation Maps with Pencil Beam XFET.IEEE transactions on radiation and plasma medical sciences · 2023
    Article
  15. A model of modifiedRSC advances · 2021
    Article
  16. A detailed experimental and Monte Carlo analysis of gold nanoparticle dose enhancement using 6 MV and 18 MV external beam energies in a macroscopic scale.Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine · 2021
    Article
  17. Intercomparison of Monte Carlo calculated dose enhancement ratios for gold nanoparticles irradiated by X-rays: Assessing the uncertainty and correct methodology for extended beams.Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) · 2021
    Article
  18. Article
  19. Article
  20. Gold nanomaterials in the management of lung cancer.Emerging topics in life sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jay F DorseyDepartment of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Lova SunDepartment of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Daniel Y JohDepartment of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Alon WitztumDepartment of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Gary D KaoDepartment of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Michelle Alonso-BasantaDepartment of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Stephen AveryDepartment of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Stephen M HahnDepartment of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Ajlan Al ZakiDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.
Andrew TsourkasDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.

Funding

Targeted Modulation of the Death Receptor as a Therapeutic Strategy for GliomaK08NS076548 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI DORSEY, JAY FITZGERALD · 2011 to 2015
$932k
NINDS NIH HHS K08 NS076548
6 · The paper itself

Abstract

The potential of gold nanoparticles (GNPs) in therapeutic and diagnostic cancer applications is becoming increasingly recognized. These biologically compatible particles can be easily synthesized, tuned to different sizes, and functionalized by conjugation to various biologically useful materials. Efficient and specific delivery to tumor tissue can then be accomplished either by passive accumulation in leaky tumor vessels and tissue, or by directly targeting tumor-specific biomarkers. Tumor-localized GNPs can serve as both adjuvants for enhancing the efficacy of radiation therapy and also as contrast agents for various imaging modalities. In this review, we will discuss recent advancements and future potential in the application of GNP as both a radiosensitizer and an imaging contrast agent. Due to their versatility and biocompatibility, gold nanoparticles may represent a novel theranostic adjuvant for radiation applications in cancer management.

Indexed as

Gold Nanoparticle (GNP)nanoscaleradiosensitizationtheranostics

Identifiers

PMID25429358
PMCPMC4241969

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.