ArticleNeuroImage. Clinical2015
Final infarct volume estimation on 1-week follow-up MR imaging is feasible and is dependent on recanalization status.
Article in NeuroImage. Clinical, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Infarct Evolution in Patients with Anterior Circulation Large-Vessel Occlusion Randomized to IV Alteplase and Endovascular Treatment versus Endovascular Treatment Alone.AJNR. American journal of neuroradiology · 2023Trial
- Trial
- Hyperemia detection on arterial spin labeling is associated with final infarct volume in stroke post-endovascular therapy.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2025Observational
- Automatic prediction of stroke treatment outcomes: latest advances and perspectives.Biomedical engineering letters · 2025Review
- Plasma brain-derived tau correlates with cerebral infarct volume.Journal of internal medicine · 2025Article
- Late Lesion Growth following Endovascular Therapy: Is 24 h Too Early to Assess Acute Infarct Size Including the Effects of Secondary Injury?Cerebrovascular diseases (Basel, Switzerland) · 2025Article
- MRI of cerebral oedema in ischaemic stroke and its current use in routine clinical practice.Neuroradiology · 2024Review
- Automated acute ischemic stroke lesion delineation based on apparent diffusion coefficient thresholds.Frontiers in neurology · 2023Article
- Prognostic value of ASPECTS on post-treatment diffusion-weighted imaging for acute ischemic stroke patients after endovascular thrombectomy: comparison with infarction volume.European radiology · 2022Article
- Duration of Ischemia Impacts Postreperfusion Clinical Outcomes Independent of Follow-Up Infarct Volume.Stroke (Hoboken, N.J.) · 2022Article
- Risk factors of late lesion growth after acute ischemic stroke treatment.Frontiers in neurology · 2022Article
- Post-stroke ASPECTS predicts outcome after thrombectomy.Neuroradiology · 2021Article
- The Role of Edema in Subacute Lesion Progression After Treatment of Acute Ischemic Stroke.Frontiers in neurology · 2021Article
- Machine learning identifies stroke features between species.Theranostics · 2021Article
- Matrix Metalloproteinase-9 Relationship With Infarct Growth and Hemorrhagic Transformation in the Era of Thrombectomy.Frontiers in neurology · 2020Article
- Increased volumes of mildly elevated capillary transit time heterogeneity positively predict favorable outcome and negatively predict intracranial hemorrhage in acute ischemic stroke with large vessel occlusion.European radiology · 2019Article
- Mediation of the Relationship Between Endovascular Therapy and Functional Outcome by Follow-up Infarct Volume in Patients With Acute Ischemic Stroke.JAMA neurology · 2019Article
- Exploratory Use of Decision Tree Analysis in Classification of Outcome in Hypoxic-Ischemic Brain Injury.Frontiers in neurology · 2018Article
- Cerebral regions preserved by successful endovascular recanalization of acute M1 segment occlusions: a voxel based analysis.The British journal of radiology · 2017Article
- Optimizing image registration and infarct definition in stroke research.Annals of clinical and translational neurology · 2017Article
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Authors and funding
6 authors.
Funding
Abstract
purposeWe aim to characterize infarct volume evolution within the first month post-ischemic stroke and to determine the effect of recanalization status on early infarct volume estimation.
methodsIschemic stroke patients recruited for the MONITOR and VISION studies were retrospectively screened and patients who had infarcts on diffusion-weighted imaging (DWI) at baseline and had at least two follow-up MR scans (n = 56) were included. Pre-defined target imaging time points, obtained on a 3-T MR scanner, were 12 hours (h), 24 h, 7 days, and ≥30 days post-stroke. Infarct tissue was manually traced blinded to the images at the other time points. Infarct expansion index was calculated by dividing infarct volume at each follow-up time point by the baseline DWI infarct volume. Recanalization was assessed within 24 h post-stroke. Correlation and statistical comparison analysis were done using the Spearman, Mann-Whitney, and Kruskal-Wallis tests.
resultsFollow-up infarct volumes were positively correlated with the baseline infarct volume (ρ > 0.81; p < 0.001) where the strongest correlation existed between baseline and 7-day post-stroke infarct volumes (ρ = 0.92; p < 0.001). The strongest correlation among the follow-up imaging was found between infarct volumes 7-day post-stroke and ≥30-day time points (ρ = 0.93; p < 0.001). Linear regression showed a close-to unity slope between 7-day and final infarct volumes (slope = 1.043; p < 0.001). Infarct expansion was higher in the non-recanalized group than the recanalized group at the 7-day (p = 0.001) and ≥30-day (p = 0.038) time points.
conclusionsFinal infarct volume can be approximated as early as 7 days post-stroke. Final infarct volume approximation is significantly associated with recanalization status.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.