ArticleCurrent protocols in neuroscience2013
Manipulating gene expression in projection-specific neuronal populations using combinatorial viral approaches.
Article in Current protocols in neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed.
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- Estradiol elicits distinct firing patterns in arcuate nucleus kisspeptin neurons of females through altering ion channel conductances.bioRxiv : the preprint server for biology · 2024Article
- Opto-seq reveals input-specific immediate-early gene induction in ventral tegmental area cell types.Neuron · 2024Article
- Mesoaccumbal glutamate neurons drive reward via glutamate release but aversion via dopamine co-release.Neuron · 2024Article
- Temporal scaling of dopamine neuron firing and dopamine release by distinct ion channels shape behavior.Science advances · 2023Article
- Whole-brain input mapping of the lateral versus medial anterodorsal bed nucleus of the stria terminalis in the mouse.Neurobiology of stress · 2023Article
- The potassium channel auxiliary subunit Kvβ2 (Journal of neurophysiology · 2022Article
- Distinct Encoding of Reward and Aversion by Peptidergic BNST Inputs to the VTA.Frontiers in neural circuits · 2022Article
- Decision Making as a Learned Skill in Mice and Humans.Frontiers in neuroscience · 2022Review
- Application of AAV1 for Anterograde Transsynaptic Circuit Mapping and Input-Dependent Neuronal Cataloging.Current protocols · 2022Article
- Noncanonical projections to the hippocampal CA3 regulate spatial learning and memory by modulating the feedforward hippocampal trisynaptic pathway.PLoS biology · 2021Article
- Autism-associated mutations in KProceedings of the National Academy of Sciences of the United States of America · 2021Article
- A midbrain dynorphin circuit promotes threat generalization.Current biology : CB · 2021Article
- CRISPR knockdown of Kcnq3 attenuates the M-current and increases excitability of NPY/AgRP neurons to alter energy balance.Molecular metabolism · 2021Article
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3 authors.
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Abstract
The mammalian brain contains tremendous structural and genetic complexity that is vital for its function. The elucidation of gene expression profiles in the brain, coupled with the development of large-scale connectivity maps and emerging viral vector-based approaches for target-selective gene manipulation, now allow for detailed dissection of gene-circuit interfaces. This protocol details how to perform combinatorial viral injections to manipulate gene expression in subsets of neurons interconnecting two brain regions. This method utilizes stereotaxic injection of a retrograde transducing CAV2-Cre virus into one brain region, combined with injection of a locally transducing Cre-dependent AAV virus into another brain region. This technique is widely applicable to the genetic dissection of neural circuitry, as it enables selective expression of candidate genes, dominant-negatives, fluorescent reporters, or genetic tools within heterogeneous populations of neurons based upon their projection targets.
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