ReviewTherapeutics and clinical risk management2014
A systematic review of the outcomes of osteoporotic fracture patients after hospital discharge: morbidity, subsequent fractures, and mortality.
Review in Therapeutics and clinical risk management, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03130673 (Hip Fracture Epidemiology at Hospital Regional Rafael Hernandez. September 2014 to March 2015.), which is not on this map. Cited by 128 papers, 8 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Hip Fracture Epidemiology at Hospital Regional Rafael Hernandez. September 2014 to March 2015.
Who cites it
128 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- Health and adverse events associated with extended oral bisphosphonates among postmenopausal women: a systematic review.The Journal of clinical endocrinology and metabolism · 2026Pooled it
- Prevalent osteoporosis and fracture risk in patients with hepatic cirrhosis: a systematic review and meta-analysis.BMC gastroenterology · 2025Pooled it
- Clinical Practice Guideline: The Diagnosis and Treatment of Osteoporosis.Deutsches Arzteblatt international · 2025Guideline
- Racial and ethnic difference in the risk of fractures in the United States: a systematic review and meta-analysis.Scientific reports · 2023Pooled it
- Correlation between neutrophil-to-lymphocyte ratio and postoperative mortality in elderly patients with hip fracture: a meta-analysis.Journal of orthopaedic surgery and research · 2021Pooled it
- Qianggu capsule for the treatment of primary osteoporosis: evidence from a Chinese patent medicine.BMC complementary and alternative medicine · 2017Pooled it
- Total flavonoids from Rhizoma Drynariae (Gusuibu) for treating osteoporotic fractures: implication in clinical practice.Drug design, development and therapy · 2017Pooled it
- Risk factors for hospital re-presentation among older adults following fragility fractures: a systematic review and meta-analysis.BMC medicine · 2016Pooled it
- Monthly treatment with romosozumab for 1 year increases bone mineral at the hip, but not the knee, in women with chronic spinal cord injury.JBMR plus · 2024Trial
- Zoledronic acid after spinal cord injury mitigates losses in proximal femoral strength independent of ambulation ability.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023Trial
- Romosozumab efficacy and safety in European patients enrolled in the FRAME trial.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022Trial
- Trial
- Bariatric Surgery Decreases the Risk of Non-traffic Accident-Related Fractures in Patients with Obesity: Real-world Data from Taiwan.Obesity surgery · 2021Trial
- Does spinopelvic alignment affect the union status in thoracolumbar osteoporotic vertebral compression fracture?European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2017Trial
- Denosumab-efficacy, safety, persistence and sequential strategies-a systematic review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Review
- One-year mortality and functional outcome of inpatients aged 85 and older with thoracolumbar vertebral fractures: differences between operative and conservative treatment.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Identification of factors predictive of contralateral secondary hip fractures in patients after initial hip fracture - A prospective observational study.Bone reports · 2026Article
- Evaluating an Artificial Intelligence software for opportunistic low bone mineral density and osteoporosis screening: a validation study.JBMR plus · 2026Article
- Arm circumference predicts 12-month mortality in older adults with hip fracture.European geriatric medicine · 2026Article
- Lumbar MRI-Based Deep Learning for Osteoporosis Prediction.Diagnostics (Basel, Switzerland) · 2026Article
68 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeOsteoporotic fracture is the main complication of osteoporosis. The current management is to discharge patients as early as possible so they can get back to their daily activities. Once discharged, there are three main issues relating to morbidity, mortality, and risk of a subsequent fracture that need to be addressed and discussed. Therefore, the aim of this systematic review was to summarize and evaluate the evidence from published literature, to determine the outcome of osteoporotic fracture patients after their hospital discharge.
methodsThe MEDLINE and Cumulative Index to Nursing and Allied Health Literature (CINAHL) databases were searched, using the terms "osteoporosis", "fracture", "osteoporotic fracture", "hip fracture", and "vertebral fracture". We included only human studies published in English between 2004 and 2014. The reference lists of included studies were thoroughly reviewed in search for other relevant studies.
resultsA total of 18 studies met the selection criteria. Most were observational and cohort studies. Out of all the studies, five studies looked into the morbidity, six studies looked into the risk of subsequent fractures, and seven studies looked into mortality. Vertebral fracture caused the greatest health burden, but hip fracture patients were the main users of informal care after hospital discharge. There was an increased risk of a subsequent fracture after a primary fracture compared with the control group, a cohort comparison, or the general population. Osteoporotic fractures, especially hip fractures, are associated with higher mortality rate despite the advances in the management of osteoporotic fracture cases.
conclusionThere is strong evidence to show that after hospital discharge, osteoporotic fracture patients are faced with higher morbidity, subsequent fractures, and mortality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.