Evidence map›Paper›PMID 25429222›Full record

ArticleNeuropsychiatric disease and treatment2014

Evaluation of clinical and inflammatory profile in opioid addiction patients with comorbid pain: results from a multicenter investigation.

Brittany B Dennis, M Constantine Samaan, Monica Bawor, James Paul, Carolyn Plater, Guillaume Pare, Andrew Worster, Michael Varenbut, Jeff Daiter, David C Marsh and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychiatric disease and treatment, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Heroin Abuse and/or HIV Infection Dysregulate Plasma Exosomal miRNAs.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Brittany B DennisDepartment of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada.
M Constantine SamaanDepartment of Pediatrics, Division of Pediatric Endocrinology, McMaster University, Hamilton, ON, Canada.
Monica BaworMcMaster Integrative Neuroscience Discovery and Study Program, McMaster University, Hamilton, ON, Canada.
James PaulDepartment of Anesthesia, McMaster University, Hamilton, ON, Canada.
Carolyn PlaterOntario Addiction Treatment Centres, Richmond Hill, ON, Canada.
Guillaume PareDepartment of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada.
Andrew WorsterDepartment of Medicine, Hamilton General Hospital, Hamilton, ON, Canada.
Michael VarenbutOntario Addiction Treatment Centres, Richmond Hill, ON, Canada.
Jeff DaiterOntario Addiction Treatment Centres, Richmond Hill, ON, Canada.
David C MarshOntario Addiction Treatment Centres, Richmond Hill, ON, Canada ; Northern Ontario School of Medicine, Sudbury, ON, Canada.
Dipika DesaiPopulation Genomics Program, Chanchlani Research Centre, McMaster University, Hamilton, ON, Canada.
Lehana ThabaneDepartment of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada ; Centre for Evaluation of Medicine, Hamilton, ON, Canada ; System Linked Research Unit, Hamilton, ON, Canada.
Zainab SamaanDepartment of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada ; Population Genomics Program, Chanchlani Research Centre, McMaster University, Hamilton, ON, Canada ; Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic pain is the most commonly reported comorbidity among patients with opioid addiction receiving methadone maintenance treatment (MMT), with an estimated prevalence ranging between 30% and 55%. Evidence suggests that patients with comorbid pain are at high risk for poor treatment response, including continued illicit substance use. Due to the important relationship between the presence of pain and illicit substance abuse within the MMT setting, it is imperative that we target our efforts toward understanding the characteristics of this patient population.

methodsThe primary objective of this study was to explore the clinical and inflammatory profile of MMT patients reporting comorbid pain. This multicenter study enrolled patients (n=235) on MMT for the treatment of opioid dependence. Clinical history and blood and urine data were collected. Blood samples were obtained for estimating the serum levels of inflammatory markers (tumor necrosis factor [TNF]-α, interleukin-1 receptor antagonist [IL-1ra], IL-6, IL-8, IL-10, interferon [IFN]-γ and chemokine (C-C motif) ligand 2 [CCL2]). The study objectives were addressed using a descriptive statistical summary and a multivariable logistic regression model constructed in STATA version 12.

resultsAmong the participants eligible for inclusion (n=235), serum IFN-γ level and substance abuse behavior proved to be important delineating characteristics for the detection of comorbid pain. Analysis of inflammatory profile showed IFN-γ to be significantly elevated among patients reporting comorbid pain (odds ratio [OR]: 2.02; 95% confidence interval [CI]: 1.17, 3.50; P=0.01). Patients reporting comorbid pain were also found to have an increase in positive opioid urine screens (OR: 1.02; 95% CI: 1.00, 1.03; P=0.01), indicating an increase in illicit opioid consumption.

conclusionMMT patients with comorbid pain were shown to have elevated IFN-γ and higher rates of continued opioid abuse. The ability to objectively distinguish between patients with comorbid pain may help to both improve the prediction of poor responders to MMT as well as identify treatment approaches such as anti-inflammatory medications as safe alternatives for MMT patients with comorbid pain.

Indexed as

Brief Pain InventoryCCL2IFN-γinflammatory markersinterleukinsmethadone maintenance treatmentopioid dependenceTNF-α

Identifiers

PMID25429222
PMCPMC4242695

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.