ArticleIranian journal of medical sciences2014
Healing effect of pistacia atlantica fruit oil extract in acetic Acid-induced colitis in rats.
Article in Iranian journal of medical sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 45 citations in OpenAlex.
- Pistacia atlantica can improve oxidative status in patients with metabolic dysfunction-associated fatty liver disease.Scientific reports · 2025Trial
- Antioxidant and anti-inflammatory effects of Equisetum arvense L. on acid-induced ulcerative colitis in rats.Scientific reports · 2025Article
- Article
- 1,2,3,4,6-Pentagalloyl glucose of Pistacia lentiscus can inhibit the replication and transcription processes and viral pathogenesis of SARS-COV-2.Molecular and cellular probes · 2022Article
- An evaluation of the effects of Pistacia atlantica gum hydro-alcoholic extract on the phagocytosis ability of macrophages and atherosclerosis development in hypercholesteremic rats.ARYA atherosclerosis · 2022Article
- Anti-Inflammatory, Antioxidant, and Healing-Promoting Effects ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- The Antioxidant and Anti-Inflammatory Effects ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- The Anti-Inflammatory Effect of Pistacia Lentiscus in a Rat Model of Colitis.Journal of inflammation research · 2020Article
- Comparison of Antioxidant and Anti-Inflammatory Effects of Honey and Spirulina platensis with Sulfasalazine and Mesalazine on Acetic Acid-Induced Ulcerative Colitis in Rats.Galen medical journal · 2019Article
- Wild pistachio (Iranian journal of basic medical sciences · 2018Article
- Cutaneous Wound Healing after Topical Application ofTurkish journal of pharmaceutical sciences · 2017Article
- The effect of Saqez (Avicenna journal of phytomedicineArticle
- Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundConsidering the anti-oxidant properties of Pistacia atlantica and lack of data regarding its efficacy in the treatment of ulcerative colitis, this study aims at investigating the effect of the Pistacia atlantica fruit extract in treating experimentally induced colitis in a rat model.
methodsSeventy male Sprague-Dawley rats (weighing 220±20 g) were used. All rats fasted 24 hours before the experimental procedure. The rats were randomly divided into 7 groups, each containing 10 induced colitis with 2ml acetic acid (3%). Group 1 (Asacol), group 2 (base gel) and group 7 (without treatment) were assigned as control groups. Group 3 (300 mg/ml) and group 4 (600 mg/ml) received Pistacia atlantica fruit orally. Group 5 (10% gel) and group 6 (20% gel) received Pistacia atlantica in the form of gel as enema. Macroscopic, histopathological examination and MDA measurement were carried out.
resultsAll groups revealed significant macroscopic healing in comparison with group 7 (P<0.001). Regarding microscopic findings in the treatment groups compared with group 7, the latter group differed significantly with groups 1, 2, 4 and 6 (P<0.001). There was a significant statistical difference in MDA scores of the seven treatment groups (F(5,54)=76.61, P<0.001). Post-hoc comparisons indicated that the mean±SD score of Asacol treated group (1.57±0.045) was not significantly different from groups 4 (1.62±0.024) and 6 (1.58±0.028).
conclusionOur study showed that a high dose of Pistacia atlantica fruit oil extract, administered orally and rectally can improve colitis physiologically and pathologically in a rat model, and may be efficient for ulcerative colitis.
Indexed as
Identifiers
25429174PMC4242986W1720054975What OpenQuestion holds
Registered trials
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