ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
GluN2B-containing NMDA receptors promote glutamate synapse development in hippocampal interneurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Article
- Mice carrying a GluN2B protein-truncating variant have altered NMDA receptor subunit composition and their behavior recapitulates patient phenotypes.Cellular and molecular life sciences : CMLS · 2026Article
- Absence seizures and sleep-wake abnormalities in a rat model of GRIN2B neurodevelopmental disorder.Epilepsia · 2025Article
- Interactive effects of early life adversity and adolescent basolateral amygdala activity on corticolimbic connectivity and behavior.Neurobiology of stress · 2025Article
- Loss of Grin2a causes a transient delay in the electrophysiological maturation of hippocampal parvalbumin interneurons.Communications biology · 2023Article
- Pathway-specific contribution of parvalbumin interneuron NMDARs to synaptic currents and thalamocortical feedforward inhibition.Molecular psychiatry · 2022Article
- Ketamine disrupts naturalistic coding of working memory in primate lateral prefrontal cortex networks.Molecular psychiatry · 2021Article
- Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.Pharmacological reviews · 2021Review
- Comprehensive Estimates of Potential Synaptic Connections in Local Circuits of the Rodent Hippocampal Formation by Axonal-Dendritic Overlap.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Effects of Aging on the Structure and Expression of NMDA Receptors of Somatostatin Expressing Neurons in the Mouse Hippocampus.Frontiers in aging neuroscience · 2021Article
- NETO1 Regulates Postsynaptic Kainate Receptors in CA3 Interneurons During Circuit Maturation.Molecular neurobiology · 2019Article
- The Role of AMPARs in the Maturation and Integration of Caudal Ganglionic Eminence-Derived Interneurons into Developing Hippocampal Microcircuits.Scientific reports · 2019Article
- The ontogeny of memory persistence and specificity.Developmental cognitive neuroscience · 2019Review
- Dlx1 and Dlx2 Promote Interneuron GABA Synthesis, Synaptogenesis, and Dendritogenesis.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- Hippocampal GABAergic Inhibitory Interneurons.Physiological reviews · 2017Review
- Inflammatory demyelination alters subcortical visual circuits.Journal of neuroinflammation · 2017Article
- Afferent specific role of NMDA receptors for the circuit integration of hippocampal neurogliaform cells.Nature communications · 2017Article
- Enhanced susceptibility of CA3 hippocampus to prenatal nicotine exposure.Journal of developmental origins of health and disease · 2017Article
- Determination of the connectivity of newborn neurons in mammalian olfactory circuits.Cellular and molecular life sciences : CMLS · 2017Review
- Diverse roles for ionotropic glutamate receptors on inhibitory interneurons in developing and adult brain.The Journal of physiology · 2016Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In postnatal development, GluN2B-containing NMDARs are critical for the functional maturation of glutamatergic synapses. GluN2B-containing NMDARs prevail until the second postnatal week when GluN2A subunits are progressively added, conferring mature properties to NMDARs. In cortical principal neurons, deletion of GluN2B results in an increase in functional AMPAR synapses, suggesting that GluN2B-containing NMDARs set a brake on glutamate synapse maturation. The function of GluN2B in the maturation of glutamatergic inputs to cortical interneurons is not known. To examine the function of GluN2B in interneurons, we generated mutant mice with conditional deletion of GluN2B in interneurons (GluN2B(ΔGAD67)). In GluN2B(ΔGAD67) mice interneurons distributed normally in cortical brain regions. After the second postnatal week, GluN2B(ΔGAD67) mice developed hippocampal seizures and died shortly thereafter. Before the onset of seizures, GluN2B-deficient hippocampal interneurons received fewer glutamatergic synaptic inputs than littermate controls, indicating that GluN2B-containing NMDARs positively regulate the maturation of glutamatergic input synapses in interneurons. These findings suggest that GluN2B-containing NMDARs keep the circuit activity under control by promoting the maturation of excitatory synapses in interneurons.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.