Trial reportThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Interactions between dorsolateral and ventromedial prefrontal cortex underlie context-dependent stimulus valuation in goal-directed choice.
Trial report in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
68 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Basal ganglia lateralization in different types of reward.Brain imaging and behavior · 2020Pooled it
- Trial
- The 5-HTPsychopharmacology · 2018Trial
- Two routes to a target: Visual priming for direct and indirect attentional sets.Memory & cognition · 2026Article
- The neural pathways of change: an fMRI study of the effects of behavioral change suggestions on value-based dietary decision-making.International journal of obesity (2005) · 2026Observational
- Overlapping and distinct intrinsic connectivity of hippocampal and triple networks in autistic individuals with and without a comorbid condition of ADHD.Frontiers in psychiatry · 2026Article
- Medial prefrontal cortex circuit dynamics involved in stage-specific addiction.Brain structure & function · 2025Review
- Flexible Reconfigurations of Brain Networks During Decisions With Predefined Versus Self-Generated Options.Human brain mapping · 2025Article
- Human amygdala nuclei show distinct developmental trajectories from adolescence to adulthood in functional integration with prefrontal circuitry.Cell reports · 2025Article
- Moral conviction interacts with metacognitive ability in modulating neural activity during sociopolitical decision-making.Cognitive, affective & behavioral neuroscience · 2025Article
- From attributes to value: Neural correlates of a front-of-package label on food decision-making - An fMRI study.PloS one · 2025Article
- Goal commitment is supported by vmPFC through selective attention.Nature human behaviour · 2024Article
- Discounting Future Reward in an Uncertain World.Decision (Washington, D.C.) · 2024Article
- Mapping expectancy-based appetitive placebo effects onto the brain in women.Nature communications · 2024Article
- Neural substrates on the judgment of sequential benefits and losses.Cognitive, affective & behavioral neuroscience · 2023Article
- Causal role of a neural system for separating and selecting multidimensional social cognitive information.Neuron · 2023Article
- The neural correlates of value representation: From single items to bundles.Human brain mapping · 2023Article
- Recruitment of dlPFC during dietary self-regulation predicts the transience of regulatory effects.Social cognitive and affective neuroscience · 2023Article
- Transcranial direct current stimulation impairs updating of avoidance-based associative learning.Frontiers in human neuroscience · 2023Article
- Article
8 more citing papers are in PubMed but not listed here.
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2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
External circumstances and internal bodily states often change and require organisms to flexibly adapt valuation processes to select the optimal action in a given context. Here, we investigate the neurobiology of context-dependent valuation in 22 human subjects using functional magnetic resonance imaging. Subjects made binary choices between visual stimuli with three attributes (shape, color, and pattern) that were associated with monetary values. Context changes required subjects to deviate from the default shape valuation and to integrate a second attribute to comply with the goal to maximize rewards. Critically, this binary choice task did not involve any conflict between opposing monetary, temporal, or social preferences. We tested the hypothesis that interactions between regions of dorsolateral prefrontal cortex (dlPFC) and ventromedial prefrontal cortex (vmPFC) implicated in self-control choices would also underlie the more general function of context-dependent valuation. Consistent with this idea, we found that the degree to which stimulus attributes were reflected in vmPFC activity varied as a function of context. In addition, activity in dlPFC increased when context changes required a reweighting of stimulus attribute values. Moreover, the strength of the functional connectivity between dlPFC and vmPFC was associated with the degree of context-specific attribute valuation in vmPFC at the time of choice. Our findings suggest that functional interactions between dlPFC and vmPFC are a key aspect of context-dependent valuation and that the role of this network during choices that require self-control to adjudicate between competing outcome preferences is a specific application of this more general neural mechanism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.