ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
GABA-A receptor inhibition of local calcium signaling in spines and dendrites.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
What it found
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Who cites it
55 citing papers in PubMed, 83 citations in OpenAlex.
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- Calcium signaling in postsynaptic mitochondria: mechanisms, dynamics, and role in ATP production.Frontiers in molecular neuroscience · 2025Review
- Synapses mediate the effects of different types of stress on working memory: a brain-inspired spiking neural network study.Frontiers in cellular neuroscience · 2025Article
- Isogenic iPSC-derivedFrontiers in neuroscience · 2025Article
- Expansion of epileptogenic networks via neuroplasticity in neural mass models.PLoS computational biology · 2024Article
- CCK+ Interneurons Contribute to Thalamus-Evoked Feed-Forward Inhibition in the Prelimbic Prefrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Hypernegative GABAThe journal of pain · 2024Article
- GABA Regulates Electrical Activity and Tumor Initiation in Melanoma.Cancer discovery · 2023Article
- GPCR-mediated calcium and cAMP signaling determines psychosocial stress susceptibility and resiliency.Science advances · 2023Article
- Local and long-range GABAergic circuits in hippocampal area CA1 and their link to Alzheimer's disease.Frontiers in neural circuits · 2023Review
- Spike-timing-dependent plasticity rewards synchrony rather than causality.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Interoperability of RTN1A in dendrite dynamics and immune functions in human Langerhans cells.eLife · 2022Article
- Assessing Local and Branch-specific Activity in Dendrites.Neuroscience · 2022Article
- Article
- Targeting prefrontal cortex GABAergic microcircuits for the treatment of alcohol use disorder.Frontiers in synaptic neuroscience · 2022Review
- A dopamine gradient controls access to distributed working memory in the large-scale monkey cortex.Neuron · 2021Article
- Gephyrin-Lacking PV Synapses on Neocortical Pyramidal Neurons.International journal of molecular sciences · 2021Article
- Development, Diversity, and Death of MGE-Derived Cortical Interneurons.International journal of molecular sciences · 2021Review
- Inhibitory regulation of calcium transients in prefrontal dendritic spines is compromised by a nonsense Shank3 mutation.Molecular psychiatry · 2021Article
- Behavioural impairments after exposure of neonatal mice to propofol are accompanied by reductions in neuronal activity in cortical circuitry.British journal of anaesthesia · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Cortical interneurons activate GABA-A receptors to rapidly control electrical and biochemical signaling at pyramidal neurons. Different populations of interneurons are known to uniquely target the soma and dendrites of pyramidal neurons. However, the ability of these interneurons to inhibit Ca(2+) signaling at spines and dendrites is largely unexplored. Here we use whole-cell recordings, two-photon microscopy, GABA uncaging and optogenetics to study dendritic inhibition at layer 5 (L5) pyramidal neurons in slices of mouse PFC. We first show that GABA-A receptors strongly inhibit action potential (AP)-evoked Ca(2+) signals at both spines and dendrites. We find robust inhibition over tens of milliseconds that spreads along the dendritic branch. However, we observe no difference in the amount of inhibition at neighboring spines and dendrites. We then examine the influence of interneurons expressing parvalbumin (PV), somatostatin (SOM), or 5HT3a receptors. We determine that these populations of interneurons make unique contacts onto the apical and basal dendrites of L5 pyramidal neurons. We also show that SOM and 5HT3a but not PV interneurons potently inhibit AP Ca(2+) signals via GABA-A receptors at both spines and dendrites. These findings reveal how multiple interneurons regulate local Ca(2+) signaling in pyramidal neurons, with implications for cortical function and disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.