ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Dopamine D1 and D5 receptors modulate spike timing-dependent plasticity at medial perforant path to dentate granule cell synapses.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 61 citations in OpenAlex.
- In silico investigation of the puzzling dopamine effects on excitability and synaptic plasticity in hippocampal CA1 pyramidal neurons.Scientific reports · 2025Article
- Ventral tegmental area dopamine projections to the hippocampus trigger long-term potentiation and contextual learning.Nature communications · 2024Article
- Gm527 deficiency in dentate gyrus improves memory through upregulating dopamine D1 receptor pathway.CNS neuroscience & therapeutics · 2023Article
- A brain-inspired algorithm that mitigates catastrophic forgetting of artificial and spiking neural networks with low computational cost.Science advances · 2023Article
- Adaptive control of synaptic plasticity integrates micro- and macroscopic network function.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Review
- Dopaminergic regulation of hippocampal plasticity, learning, and memory.Frontiers in behavioral neuroscience · 2022Review
- Activation of a Locus Coeruleus to Dorsal Hippocampus Noradrenergic Circuit Facilitates Associative Learning.Frontiers in cellular neuroscience · 2022Article
- Periodicity Pitch Perception Part III: Sensibility and Pachinko Volatility.Frontiers in neuroscience · 2022Article
- Cell-type-specific disruption of PERK-eIF2α signaling in dopaminergic neurons alters motor and cognitive function.Molecular psychiatry · 2021Article
- Midbrain dopaminergic innervation of the hippocampus is sufficient to modulate formation of aversive memories.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Dopamine: The Neuromodulator of Long-Term Synaptic Plasticity, Reward and Movement Control.Cells · 2021Review
- Calcium and Spike Timing-Dependent Plasticity.Frontiers in cellular neuroscience · 2021Review
- Dopaminergic Neuromodulation of Spike Timing Dependent Plasticity in Mature Adult Rodent and Human Cortical Neurons.Frontiers in cellular neuroscience · 2021Article
- Obligatory roles of dopamine D1 receptors in the dentate gyrus in antidepressant actions of a selective serotonin reuptake inhibitor, fluoxetine.Molecular psychiatry · 2020Article
- Article
- Optogenetic Manipulation of Postsynaptic cAMP Using a Novel Transgenic Mouse Line Enables Synaptic Plasticity and Enhances Depolarization Following Tetanic Stimulation in the Hippocampal Dentate Gyrus.Frontiers in neural circuits · 2020Article
- GSK3β Modulates Timing-Dependent Long-Term Depression Through Direct Phosphorylation of Kv4.2 Channels.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Neuromodulation of hippocampal long-term synaptic plasticity.Current opinion in neurobiology · 2019Review
- Acetylcholine-modulated plasticity in reward-driven navigation: a computational study.Scientific reports · 2018Article
- Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Although evidence suggests that DA modulates hippocampal function, the mechanisms underlying that dopaminergic modulation are largely unknown. Using perforated-patch electrophysiological techniques to maintain the intracellular milieu, we investigated how the activation of D1-type DA receptors regulates spike timing-dependent plasticity (STDP) of the medial perforant path (mPP) synapse onto dentate granule cells. When D1-type receptors were inhibited, a relatively mild STDP protocol induced LTP only within a very narrow timing window between presynaptic stimulation and postsynaptic response. The stimulus protocol produced timing-dependent LTP (tLTP) only when the presynaptic stimulation was followed 30 ms later by depolarization-induced postsynaptic action potentials. That is, the time between presynaptic stimulation and postsynaptic response was 30 ms (Δt = +30 ms). When D1-type receptors were activated, however, the same mild STDP protocol induced tLTP over a much broader timing window: tLTP was induced when -30 ms ≤ Δt ≤ +30 ms. The result indicated that D1-type receptor activation enabled synaptic potentiation even when postsynaptic activity preceded presynaptic stimulation within this Δt range. Results with null mice lacking the Kv4.2 potassium channel and with the potassium channel inhibitor, 4-aminopyridine, suggested that D1-type receptors enhanced tLTP induction by suppressing the transient IA-type K(+) current. Results obtained with antagonists and DA receptor knock-out mice indicated that endogenous activity of both D1 and D5 receptors modulated plasticity in the mPP. The DA D5 receptors appeared particularly important in regulating plasticity of the mPP onto the dentate granule cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.