Evidence map›Paper›PMID 25429066›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2015

A critical role for the regulated wnt-myc pathway in naive T cell survival.

Chunshu Wong, Chong Chen, Qi Wu, Yang Liu, Pan Zheng

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
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  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Wnts and the hallmarks of cancer.Cancer metastasis reviews · 2020
    Review
  14. Casein Kinase 1α as a Regulator of Wnt-Driven Cancer.International journal of molecular sciences · 2020
    Review
  15. Review
  16. Article
  17. Review
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Chunshu WongCenter for Cancer and Immunology Research, Children's National Medical Center, Washington, DC 20010; Immunology Graduate Program, Program in Biomedical Sciences, University of Michigan, Ann Arbor, MI 48109;
Chong ChenDepartment of Surgery, University of Michigan, Ann Arbor, MI 48109;
Qi WuDepartment of Neurology, University of Michigan, Ann Arbor, MI 48109; and.
Yang LiuCenter for Cancer and Immunology Research, Children's National Medical Center, Washington, DC 20010; pzheng@cnmc.org yaliu@cnmc.org.
Pan ZhengCenter for Cancer and Immunology Research, Children's National Medical Center, Washington, DC 20010; Division of Pathology, Children's National Medical Center, Washington, DC 20010 pzheng@cnmc.org yaliu@cnmc.org.ORCID http://orcid.org/0000-0003-2598-3544
Children's National · USUniversity of Michigan · US

Funding

RESEARCH TRAINING IN EXPERIMENTAL IMMUNOPATHOLOGYT32AI007413 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Bethany B. Moore · 1993 to 2026
$9.8M
Checkpoints of Host Response to Cellular InjuriesR01AI064350 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LIU, YANG, ZHENG, PAN · 2006 to 2019
$5.6M
mTOR, Inflammation and Senescence of Hematopoietic Stem CellsR01AG036690 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZHENG, PAN · 2010 to 2014
$1.6M
Selective Modulation of Cancer Immunity and AutoimmunityR01CA112001 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LIU, YANG · 2006 to 2010
$1.3M
NCI NIH HHS R01 CA112001NIAID NIH HHS R01 AI064350NIAID NIH HHS R01 AI64350NIAID NIH HHS T32 AI007413NIAID NIH HHS T32AI007413NIA NIH HHS R01 AG036690NIA NIH HHS R01 AG036690-A1
6 · The paper itself

Abstract

Wnt signaling is involved in T cell development, activation, and differentiation. However, the role for Wnt signaling in mature naive T cells has not been investigated. In this article, we report that activation of Wnt signaling in T cell lineages by deletion of the Apc (adenomatous polyposis coli) gene causes spontaneous T cell activation and severe T cell lymphopenia. The lymphopenia is the result of rapid apoptosis of newly exported, mature T cells in the periphery and is not due to defects in thymocyte development or emigration. Using chimera mice consisting of both wild-type and Apc-deficient T cells, we found that loss of naive T cells is due to T cell intrinsic dysregulation of Wnt signaling. Because Apc deletion causes overexpression of the Wnt target gene cMyc, we generated mice with combined deletion of the cMyc gene. Because combined deletion of cMyc and Apc attenuated T cell loss, cMyc overexpression is partially responsible for spontaneous T cell apoptosis and lymphopenia. Cumulatively, our data reveal a missing link between Wnt signaling and survival of naive T cells.

Indexed as

Adenomatous Polyposis Coli ProteinAdoptive TransferAnimalsApoptosisbeta CateninCell DifferentiationCell LineageCell SurvivalGene Knock-In TechniquesLymphocyte ActivationLymphopeniaMiceMice, Inbred C57BLMice, KnockoutProto-Oncogene Proteins c-mycT-LymphocytesAdenomatous Polyposis Coli Proteinbeta CateninMyc protein, mouseProto-Oncogene Proteins c-mycWnt Proteins

Identifiers

PMID25429066
PMCPMC4272883
OpenAlexW1839703623

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.