SynthesisHuman molecular genetics2015
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
Abstract readMeta-Analysis
In one paragraph
Synthesis in Human molecular genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 4 of them syntheses that pooled it.
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59citing papers in PubMed, 4 pooled it
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What it found
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Who cites it
59 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Combined genome-wide association study of 136 quantitative ear morphology traits in multiple populations reveal 8 novel loci.PLoS genetics · 2023Pooled it
- A unified method for rare variant analysis of gene-environment interactions.Statistics in medicine · 2020Pooled it
- Genome-wide meta-analysis identifies novel loci associated with parathyroid hormone level.Molecular medicine (Cambridge, Mass.) · 2018Pooled it
- Height and Breast Cancer Risk: Evidence From Prospective Studies and Mendelian Randomization.Journal of the National Cancer Institute · 2015Pooled it
- Genetic Variation in Steroid and Xenobiotic Metabolizing Pathways and Enterolactone Excretion Before and After Flaxseed Intervention in African American and European American Women.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2019Trial
- Admixture mapping and fine-mapping of birth weight loci in the Black Women's Health Study.Human genetics · 2018Trial
- Identification of regulatory loci and candidate genes related to body weight traits in broilers based on different models.BMC genomics · 2025Article
- QSOX2 Deficiency-induced short stature, gastrointestinal dysmotility and immune dysfunction.Nature communications · 2024Article
- Forensic height estimation using polygenic score in Korean population.Molecular genetics and genomics : MGG · 2024Article
- Novel signals and polygenic score for height are associated with pubertal growth traits in Southwestern American Indians.Human molecular genetics · 2024Article
- The association between DNA methylation and human height and a prospective model of DNA methylation-based height prediction.Human genetics · 2024Article
- Applications of genomic research in pediatric endocrine diseases.Clinical and experimental pediatrics · 2023Article
- Analysis of GPR126 polymorphisms and their relationship with scoliosis in Marfan syndrome and Marfan-like syndrome in Mexican patients.Biomolecules & biomedicine · 2023Article
- Human height: a model common complex trait.Annals of human biology · 2023Review
- Sox, Fox, and Lmx1b binding sites differentially regulate a Gdf5-Associated regulatory region during elbow development.Frontiers in cell and developmental biology · 2023Article
- Emerging roles of centrosome cohesion.Open biology · 2022Review
- The association of age at menarche and adult height with mammographic density in the International Consortium of Mammographic Density.Breast cancer research : BCR · 2022Article
- Your height affects your health: genetic determinants and health-related outcomes in Taiwan.BMC medicine · 2022Article
- Admixture mapping of anthropometric traits in the Black Women's Health Study: evidence of a shared African ancestry component with birth weight and type 2 diabetes.Journal of human genetics · 2022Article
- Polymorphisms in the mTOR-PI3K-Akt pathway, energy balance-related exposures and colorectal cancer risk in the Netherlands Cohort Study.BioData mining · 2022Article
Corrections and comments
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Authors and funding
90 authors.
Meian HeMOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Hubei, Wuhan 430030, China, hemeian@hotmail.com.
Min XuDepartment of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA, Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism and.
Ben ZhangVanderbilt Epidemiology Center, Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Jun LiangDepartment of Endocrinology, The Central Hospital of Xuzhou, Affiliated Hospital of Southeast University, Xuzhou, Jiangsu 221009, China.
Peng ChenSaw Swee Hock School of Public Health.
Jong-Young LeeCenter for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do 363-700, Republic of Korea.
Todd A JohnsonLaboratory for Medical Informatics.
Huaixing LiKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Xiaobo YangInstitute of Urology and Nephrology, First Affiliated Hospital & Center for Genomic and Personalized Medicine, Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning, Guangxi 530021, China.
Juncheng DaiDepartment of Epidemiology & Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 210029, China.
Liming LiangDepartment of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA.
Lixuan GuiMOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Hubei, Wuhan 430030, China.
Qibin QiDepartment of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA.
Jinyan HuangDepartment of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA.
Yanping LiDepartment of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA.
Linda S AdairDepartment of Nutrition and.
Tin AungSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore 168751.
Qiuyin CaiVanderbilt Epidemiology Center, Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Ching-Yu ChengSaw Swee Hock School of Public Health, Department of Ophthalmology, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore 168751, Duke-National University of Singapore Graduate Medical School, Singapore, Singapore 169857.
Myeong-Chan ChoCenter for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do 363-700, Republic of Korea.
Yoon Shin ChoCenter for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do 363-700, Republic of Korea.
Minjie ChuDepartment of Epidemiology & Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 210029, China.
Bin CuiKey Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism and.
Yu-Tang GaoDepartment of Epidemiology, Shanghai Cancer Institute, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Min Jin GoCenter for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do 363-700, Republic of Korea.
Dongfeng GuState Key Laboratory of Cardiovascular Disease, Department of Evidence Based Medicine, Fuwai Hospital, National Center of Cardiovascular Diseases.
Weiqiong GuKey Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism and.
Huan GuoMOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Hubei, Wuhan 430030, China.
Yongchen HaoState Key Laboratory of Cardiovascular Disease, Department of Evidence Based Medicine, Fuwai Hospital, National Center of Cardiovascular Diseases.
Jie HongKey Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism and.
Zhibin HuDepartment of Epidemiology & Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 210029, China.
Yanling HuMedical Scientific Research Center and.
Jianfeng HuangState Key Laboratory of Cardiovascular Disease, Department of Evidence Based Medicine, Fuwai Hospital, National Center of Cardiovascular Diseases.
Joo-Yeon HwangCenter for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do 363-700, Republic of Korea.
Mohammad Kamran IkramSaw Swee Hock School of Public Health, Department of Ophthalmology, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore 168751, Department of Ophthalmology, Erasmus Medical Center, Rotterdam 3015, The Netherlands, Memory Aging & Cognition Centre, National University Health System, Singapore, Singapore 119228.
Guangfu JinDepartment of Epidemiology & Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 210029, China.
Dae-Hee KangDepartment of Preventive Medicine, Seoul National University, College of Medicine, Seoul 110-799, Republic of Korea.
Chiea Chuen KhorSaw Swee Hock School of Public Health, Department of Ophthalmology, Department of Paediatrics National University Health Systems, Agency for Science, Technology and Research, Genome Institute of Singapore, Singapore, Singapore 138672.
Bong-Jo KimCenter for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do 363-700, Republic of Korea.
Hung Tae KimCenter for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do 363-700, Republic of Korea.
Michiaki KuboLaboratory for Genotyping Development.
Jeannette LeeSaw Swee Hock School of Public Health.
Juyoung LeeCenter for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do 363-700, Republic of Korea.
Nanette R LeeOffice of Population Studies Foundation, University of San Carlos, Cebu City 6000, Philippines.
Ruoying LiDepartment of Medicine, Yong Loo Lin School of Medicine.
Jun LiMOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Hubei, Wuhan 430030, China.
JianJun LiuSaw Swee Hock School of Public Health, Agency for Science, Technology and Research, Genome Institute of Singapore, Singapore, Singapore 138672.
Jirong LongeVanderbilt Epidemiology Center, Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Wei LuShanghai Municipal Center for Disease Control & Prevention, 1380 Zhong Shan Road (W), Shanghai 200336, China.
Xiangfeng LuState Key Laboratory of Cardiovascular Disease, Department of Evidence Based Medicine, Fuwai Hospital, National Center of Cardiovascular Diseases.
Xiaoping MiaoMOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Hubei, Wuhan 430030, China.
Yukinori OkadaLaboratory for Statistical Analysis.
Rick Twee-Hee OngSaw Swee Hock School of Public Health.
Gaokun QiuMOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Hubei, Wuhan 430030, China.
Mark SeielstadDepartment of Paediatrics National University Health Systems.
Xueling SimSaw Swee Hock School of Public Health, Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109-2029, USA.
Huaidong SongState Key Laboratory of Medical Genomics, Molecular Medical Center, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Fumihiko TakeuchiDepartment of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo 162-8655, Japan.
Toshihiro TanakaLaboratory for Cardiovascular Diseases, RIKEN Center for Genomic Medicine, Yokohama 230-0045, Japan.
Phil R TaylorDivision of Cancer Epidemiology & Genetics, Genetic Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892, USA.
Laiyuan WangState Key Laboratory of Cardiovascular Disease, Department of Evidence Based Medicine, Fuwai Hospital, National Center of Cardiovascular Diseases.
Weiqing WangKey Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism and.
Yiqin WangKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Chen WuState Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Ying WuDepartment of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.
Yong-Bing XiangDepartment of Epidemiology, Shanghai Cancer Institute, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Ken YamamotoDepartment of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan.
Handong YangDepartment of Cardiology, Dongfeng Central Hospital, Dongfeng Motor Corporation and Hubei University of Medicine, Shiyan, Hubei 442008, China.
Ming LiaoInstitute of Urology and Nephrology, First Affiliated Hospital & Center for Genomic and Personalized Medicine.
Mitsuhiro YokotaDepartment of Genome Science, Aichi-Gakuin University, School of Dentistry, Nagoya 464-8650, Japan.
Terri YoungDuke-National University of Singapore Graduate Medical School, Singapore, Singapore 169857, Duke Eye Center, Duke University Medical Center, Durham, NC 27710, USA.
Xiaomin ZhangMOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Hubei, Wuhan 430030, China.
Norihiro KatoDepartment of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo 162-8655, Japan.
Qing K WangKey Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China.
Wei ZhengVanderbilt Epidemiology Center, Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Frank B HuDepartment of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA.
Dongxin LinState Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Hongbing ShenDepartment of Epidemiology & Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 210029, China.
Yik Ying TeoSaw Swee Hock School of Public Health, NUS Graduate School for Integrative Science and Engineering, Life Sciences Institute, Department of Statistics and Applied Probability, National University of Singapore, Singapore, Singapore 119077, Agency for Science, Technology and Research, Genome Institute of Singapore, Singapore, Singapore 138672.
Zengnan MoInstitute of Urology and Nephrology, First Affiliated Hospital & Center for Genomic and Personalized Medicine.
Tien Yin WongDepartment of Ophthalmology, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore 168751.
Xu LinKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Karen L MohlkeDepartment of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.
Guang NingKey Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism and.
Tatsuhiko TsunodaLaboratory for Medical Informatics.
Bok-Ghee HanCenter for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do 363-700, Republic of Korea.
Xiao-Ou ShuVanderbilt Epidemiology Center, Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
E Shyong TaiSaw Swee Hock School of Public Health, Department of Medicine, Yong Loo Lin School of Medicine, Duke-National University of Singapore Graduate Medical School, Singapore, Singapore 169857.
Tangchun WuMOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Hubei, Wuhan 430030, China.
Lu QiDepartment of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA.
Funding
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3MUNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ian Michael Carroll · 1999 to 2026
$31.6MTransgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI CORKEY, BARBARA E. · 1992 to 2021
$25.0MCohort Study of Cancer inhibitory Factors in MenR01CA082729 · NCI · VANDERBILT UNIVERSITY · PI SHU, XIAO-OU · 2001 to 2011
$6.3MShanghai Womens Health StudyUM1CA182910 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ZHENG, WEI · 2014 to 2018
$5.9MCommon Genetic Variation and Quantitative Diabetes TraitsR01DK078616 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI MEIGS, JAMES B · 2008 to 2014
$5.0MShanghai Men's Health StudyUM1CA173640 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SHU, XIAO-OU · 2013 to 2017
$4.9MGenetic Markers of CHD in Type 2 DiabetesR01HL071981 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI QI, LU · 2003 to 2012
$4.9MShanghai Breast Cancer StudyR01CA064277 · NCI · VANDERBILT UNIVERSITY · PI SHU, XIAO-OU · 1996 to 2012
$4.8MCancer Risk Reduction and Diet: A Cohort Study of WomenR37CA070867 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ZHENG, WEI · 2009 to 2013
$4.7MObesity Genes, Energy Regulation in Response to Weight-Loss DietsR01DK091718 · NIDDK · TULANE UNIVERSITY OF LOUISIANA · PI QI, LU · 2012 to 2021
$4.5MTOPMed Omics of Type 2 Diabetes and Quantitative TraitsUM1DK078616 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI MANNING, ALISA KNODLE · 2021 to 2025
$3.8MFIC NIH HHS R01 TW005596FIC NIH HHS TW05596NCI NIH HHS R01 CA064277NCI NIH HHS R01CA064277NCI NIH HHS R01 CA082729NCI NIH HHS R01CA082729NCI NIH HHS R01 CA092585NCI NIH HHS R01CA092585NCI NIH HHS R01 CA122364NCI NIH HHS R01CA122364NCI NIH HHS R01 CA124558NCI NIH HHS R01CA124558NCI NIH HHS R01 CA148667NCI NIH HHS R01CA148667NCI NIH HHS R01CA82729NCI NIH HHS R37 CA070867NCI NIH HHS R37CA070867NCI NIH HHS R37CA070867,NCI NIH HHS UM1 CA173640NCI NIH HHS UM1 CA182910NCRR NIH HHS P20 RR020649NCRR NIH HHS RR20649NHLBI NIH HHS HL071981NHLBI NIH HHS HL085144NHLBI NIH HHS R01 HL071981NHLBI NIH HHS R01 HL085144NIDDK NIH HHS DK078150NIDDK NIH HHS DK078616NIDDK NIH HHS DK091718NIDDK NIH HHS DK46200NIDDK NIH HHS DK56350NIDDK NIH HHS P30 DK046200NIDDK NIH HHS P30 DK056350NIDDK NIH HHS R01 DK078150NIDDK NIH HHS R01 DK078616NIDDK NIH HHS R01 DK091718NIDDK NIH HHS U01 DK078616NIDDK NIH HHS UM1 DK078616NIEHS NIH HHS ES10126NIEHS NIH HHS P30 ES010126
Abstract
Human height is associated with risk of multiple diseases and is profoundly determined by an individual's genetic makeup and shows a high degree of ethnic heterogeneity. Large-scale genome-wide association (GWA) analyses of adult height in Europeans have identified nearly 180 genetic loci. A recent study showed high replicability of results from Europeans-based GWA studies in Asians; however, population-specific loci may exist due to distinct linkage disequilibrium patterns. We carried out a GWA meta-analysis in 93 926 individuals from East Asia. We identified 98 loci, including 17 novel and 81 previously reported loci, associated with height at P < 5 × 10(-8), together explaining 8.89% of phenotypic variance. Among the newly identified variants, 10 are commonly distributed (minor allele frequency, MAF > 5%) in Europeans, with comparable frequencies with in Asians, and 7 single-nucleotide polymorphisms are with low frequency (MAF < 5%) in Europeans. In addition, our data suggest that novel biological pathway such as the protein tyrosine phosphatase family is involved in regulation of height. The findings from this study considerably expand our knowledge of the genetic architecture of human height in Asians.
Indexed as
Polymorphism, Single NucleotideAdolescentAdultAgedAged, 80 and overAsia, EasternAsian PeopleBody HeightFemaleGene FrequencyGenetic LociGenome-Wide Association StudyHumansMaleMetabolic Networks and PathwaysMiddle AgedProtein Tyrosine Phosphatases
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