ArticleSchizophrenia bulletin2015
Converging evidence implicates the abnormal microRNA system in schizophrenia.
Article in Schizophrenia bulletin, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- What genes are differentially expressed in individuals with schizophrenia? A systematic review.Molecular psychiatry · 2022Pooled it
- Epigenetic mechanisms in schizophrenia and other psychotic disorders: a systematic review of empirical human findings.Molecular psychiatry · 2020Pooled it
- Genetic association and meta-analysis of a schizophrenia GWAS variant rs10489202 in East Asian populations.Translational psychiatry · 2018Pooled it
- Revealing the Oxidative Stress-Related Molecular Characteristics and Potential Therapeutic Targets of Schizophrenia through Integrated Gene Expression Data Analysis.Molecular neurobiology · 2025Article
- Circulating microRNA Profiles Identify a Patient Subgroup with High Inflammation and Severe Symptoms in Schizophrenia Experiencing Acute Psychosis.International journal of molecular sciences · 2024Article
- Longitudinal MicroRNA Signature of Conversion to Psychosis.Schizophrenia bulletin · 2024Article
- A Potential Immune-Related miRNAs Regulatory Network and Corresponding Diagnostic Efficacy in Schizophrenia.Neurochemical research · 2023Article
- Deregulatory miRNA-BDNF Network Inferred from Dynamic Expression Changes in Schizophrenia.Brain sciences · 2022Article
- Neurodevelopment regulators miR-137 and miR-34 family as biomarkers for early and adult onset schizophrenia.NPJ schizophrenia · 2021Article
- A Potential Autophagy-Related Competing Endogenous RNA Network and Corresponding Diagnostic Efficacy in Schizophrenia.Frontiers in psychiatry · 2021Article
- Widespread transcriptional disruption of the microRNA biogenesis machinery in brain and peripheral tissues of individuals with schizophrenia.Translational psychiatry · 2020Article
- Rs7219 Regulates the Expression of GRB2 by Affecting miR-1288-Mediated Inhibition and Contributes to the Risk of Schizophrenia in the Chinese Han Population.Cellular and molecular neurobiology · 2019Article
- Article
- Dysregulation of miRNA and its potential therapeutic application in schizophrenia.CNS neuroscience & therapeutics · 2018Review
- Non-Coding RNA as Novel Players in the Pathophysiology of Schizophrenia.Non-coding RNA · 2018Review
- The Role of microRNA Expression in Cortical Development During Conversion to Psychosis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- Progress in genome-wide association studies of schizophrenia in Han Chinese populations.NPJ schizophrenia · 2017Review
- MicroRNA-137 Inhibits EFNB2 Expression Affected by a Genetic Variant and Is Expressed Aberrantly in Peripheral Blood of Schizophrenia Patients.EBioMedicine · 2016Article
- Exploring Transcription Factors-microRNAs Co-regulation Networks in Schizophrenia.Schizophrenia bulletin · 2016Article
- Increased Variability of Genomic Transcription in Schizophrenia.Scientific reports · 2015Article
Corrections and comments
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Authors and funding
19 authors at 8 institutions in 4 countries.
Funding
Abstract
backgroundPrevious findings are inconsistent; yet, converging evidence suggests an association between schizophrenia (SZ) and the impairment of posttranscriptional regulation of brain development through microRNA (miRNA) systems.
methodsThis study aims to (1) compare the overall frequency of 121 rare variants (RVs) in 59 genes associated with the miRNA system in genome-wide association studies (GWAS)-derived data including 768 SZ cases and 1348 healthy controls and validated in an independent GWAS data including 1802 SZ cases and 1447 controls; (2) profile genome-wide miRNA expression in blood collected from 15 early-onset SZ (EOS) cases and 15 healthy controls; and (3) construct a miRNA-messenger RNA (mRNA) regulatory network using our previous genome-wide mRNA expression data generated from a separate sample of 18 EOS cases and 12 healthy controls.
resultsOur findings indicate that: (1) In genes associated with the control of miRNAs, there are approximately 50% more RVs in SZ cases than in controls (P ≤ 2.62E-10); (2) The observed lower miRNA activity in EOS patients compared with the healthy controls suggests that miRNAs are abnormally downregulated; (3) There exists a predicted regulatory network among some downregulated miRNAs and some upregulated mRNAs.
conclusionsCollectively, results from all 3 lines of evidence, suggest that the genetically based dysregulation of miRNA systems undermines miRNAs' inhibitory effects, resulting in the abnormal upregulation of genome transcription in the development of SZ.
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