ArticleProceedings. Biological sciences2015
Could the human papillomavirus vaccines drive virulence evolution?
Article in Proceedings. Biological sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Mathematical modelling of the role of Langerhans cells in the dynamics of HPV infection.Scientific reports · 2025Article
- Within- and between-host evolutionary effects on viral oncogenicity.Virus evolution · 2025Article
- Viral and immune dynamics of genital human papillomavirus infections in young women with high temporal resolution.PLoS biology · 2025Observational
- Episome partitioning and symmetric cell divisions: Quantifying the role of random events in the persistence of HPV infections.PLoS computational biology · 2021Article
- Human Papillomavirus Genotype Replacement: Still Too Early to Tell?The Journal of infectious diseases · 2021Article
- NanoString Technology for Human Papillomavirus Typing.Viruses · 2021Article
- Review
- Prophylactic host behaviour discourages pathogen exploitation.Journal of theoretical biology · 2020Article
- Host exposure history modulates the within-host advantage of virulence in a songbird-bacterium system.Scientific reports · 2019Article
- Article
- Article
- Modelling the evolution of viral oncogenesis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- Host contact dynamics shapes richness and dominance of pathogen strains.PLoS computational biology · 2019Article
- The influence of social behaviour on competition between virulent pathogen strains.Journal of theoretical biology · 2018Article
- Recurring infection with ecologically distinct HPV types can explain high prevalence and diversity.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Why Human Papillomavirus Acute Infections Matter.Viruses · 2017Review
- Mechanistic mathematical models: An underused platform for HPV research.Papillomavirus research (Amsterdam, Netherlands) · 2017Review
- Modeling the Mechanisms by Which HIV-Associated Immunosuppression Influences HPV Persistence at the Oral Mucosa.PloS one · 2017Article
- Combined SYBR Green real-time polymerase chain reaction and microarray method for the simultaneous determination of human papillomavirus loads and genotypes.Obstetrics & gynecology science · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The human papillomavirus (HPV) vaccines hold great promise for preventing several cancers caused by HPV infections. Yet little attention has been given to whether HPV could respond evolutionarily to the new selection pressures imposed on it by the novel immunity response created by the vaccine. Here, we present and theoretically validate a mechanism by which the vaccine alters the transmission-recovery trade-off that constrains HPV's virulence such that higher oncogene expression is favoured. With a high oncogene expression strategy, the virus is able to increase its viral load and infected cell population before clearance by the vaccine, thus improving its chances of transmission. This new rapid cell-proliferation strategy is able to circulate between hosts with medium to high turnover rates of sexual partners. We also discuss the importance of better quantifying the duration of challenge infections and the degree to which a vaccinated host can shed virus. The generality of the models presented here suggests a wider applicability of this mechanism, and thus highlights the need to investigate viral oncogenicity from an evolutionary perspective.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.