Evidence map›Paper›PMID 25429009›Full record

ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2015

Associations of Heart Rate With Inflammatory Markers Are Modulated by Gender and Obesity in Older Adults.

Alice Laudisio, Stefania Bandinelli, Antonella Gemma, Luigi Ferrucci, Raffaele Antonelli Incalzi

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Alice LaudisioDepartment of Geriatrics, Campus Bio-Medico University, Rome, Italy. lavoralice@gmail.com.
Stefania BandinelliGeriatric Rehabilitation Unit, Azienda Sanitaria di Firenze, Florence, Italy.
Antonella GemmaDepartment of Homecare Service, Azienda Sanitaria Locale Roma E, Rome, Italy.
Luigi FerrucciNational Institute on Aging, National Institutes of Health, Baltimore, Maryland.
Raffaele Antonelli IncalziDepartment of Geriatrics, Campus Bio-Medico University, Rome, Italy.
Università Campus Bio-Medico · ITAzienda Sanitaria di Firenze · ITAzienda Sanitaria Locale Roma 3 · ITNational Institute on Aging · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFaster resting heart rate (HR), which is associated with inflammation and elevated cortisol levels, is a risk factor for excess cardiovascular morbidity and mortality. Obesity is associated with increased cardiovascular morbidity and mortality, inflammation, and elevated cortisol levels. The aim of the present study was to evaluate the interaction of Body Mass Index (BMI) with inflammation and cortisol in modulating HR in older subjects.

methodsWe analyzed data of 895 participants aged 65+ enrolled in the "InCHIANTI" study, in sinus rhythm, and not taking beta blockers or digoxin. Linear regression was performed to assess the adjusted association between HR, IL-6, and cortisol levels. The model was also analyzed stratifying for BMI tertiles. Logistic regression was adopted for evaluating the association of HR exceeding the mean value with Il-6 and serum cortisol.

resultsAccording to multivariable linear regression, IL-6 and cortisol levels were associated with HR (B = 1.42, 95% CI = 0.43-2.42; p = .005 and B = .34, 95% CI = 0.17-.51; p < .0001, respectively). The association was significant only among women in the highest BMI tertile (B = 4.16, 95% CI = 1.40-6.91; p = .003 for IL-6 and B = .57, 95% CI = 0.14-1.01; p = .010 for cortisol). Logistic regression confirmed that IL-6 and cortisol levels were associated with HR above the mean value in the highest BMI tertile (OR = 2.13, 95% CI = 1.15-3.97; p = .009 and OR = 1.14, 95% CI = 1.03-1.25; p = .009, respectively).

conclusionsFaster HR is associated with proinflammatory state in elderly patients; this association seems to be limited to women with higher BMI.

Indexed as

AgedAged, 80 and overAge FactorsBiomarkersBody Mass IndexCohort StudiesFemaleHeart RateHumansHydrocortisoneInterleukin-6ItalyMaleObesitySex FactorsBiomarkersHydrocortisoneInterleukin-6Body mass indexElderlyEpidemiologyHeart rateInflammation

Identifiers

PMID25429009
PMCPMC4481689
OpenAlexW1972068173

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.