ArticleJournal of experimental botany2015
Differential inhibition of Arabidopsis superoxide dismutases by peroxynitrite-mediated tyrosine nitration.
Article in Journal of experimental botany, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 129 citations in OpenAlex.
- From Abiotic Stress to Emerging Environmental Pollutants: Expanding Roles of Melatonin and NO in Plant Defense.International journal of molecular sciences · 2026Review
- Linking Superoxide Production and Scavenging in Plant Development.Plant, cell & environment · 2026Review
- Peroxynitrite-mediated tyrosine nitration modulates β-1,3-glucanase activity and potato defense againstFrontiers in plant science · 2026Article
- Dynamic ASK1 proximity networks uncover SCF-dependent and noncanonical roles in ABA and drought adaptation.bioRxiv : the preprint server for biology · 2025Article
- Progress in Plant Nitric Oxide Studies: Implications for Phytopathology and Plant Protection.International journal of molecular sciences · 2025Review
- Exogenous Sodium Nitroprusside Affects the Redox System of Wheat Roots Differentially Regulating the Activity of Antioxidant Enzymes under Short-Time Osmotic Stress.Plants (Basel, Switzerland) · 2024Article
- Mitochondrial alternative oxidase pathway helps in nitrooxidative stress tolerance in germinating chickpea.Journal of biosciences · 2024Article
- Fine-tuned nitric oxide and hormone interface in plant root development and regeneration.Journal of experimental botany · 2023Review
- In Silico RNAseq and Biochemical Analyses of Glucose-6-Phosphate Dehydrogenase (G6PDH) from Sweet Pepper Fruits: Involvement of Nitric Oxide (NO) in Ripening and Modulation.Plants (Basel, Switzerland) · 2023Article
- Mitochondria in photosynthetic cells: Coordinating redox control and energy balance.Plant physiology · 2023Article
- Nitric Oxide Acts as a Key Signaling Molecule in Plant Development under Stressful Conditions.International journal of molecular sciences · 2023Review
- Functions of NO and HMethods in molecular biology (Clifton, N.J.) · 2023Article
- Review
- Signaling by reactive molecules and antioxidants in legume nodules.The New phytologist · 2022Review
- Peroxisome-Mediated Reactive Oxygen Species Signals Modulate Programmed Cell Death in Plants.International journal of molecular sciences · 2022Review
- Potential Utility of Natural Products against Oxidative Stress in Animal Models of Multiple Sclerosis.Antioxidants (Basel, Switzerland) · 2022Review
- Nitric Oxide (NO) Differentially Modulates the Ascorbate Peroxidase (APX) Isozymes of Sweet Pepper (Antioxidants (Basel, Switzerland) · 2022Article
- Redox post-translational modifications and their interplay in plant abiotic stress tolerance.Frontiers in plant science · 2022Review
- Protein Tyrosine Nitration in Plant Nitric Oxide Signaling.Frontiers in plant science · 2022Review
- Peroxisomes as redox-signaling nodes in intracellular communication and stress responses.Plant physiology · 2021Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the importance of superoxide dismutases (SODs) in the plant antioxidant defence system little is known about their regulation by post-translational modifications. Here, we investigated the in vitro effects of nitric oxide derivatives on the seven SOD isoforms of Arabidopsis thaliana. S-nitrosoglutathione, which causes S-nitrosylation of cysteine residues, did not influence SOD activities. By contrast, peroxynitrite inhibited the mitochondrial manganese SOD1 (MSD1), peroxisomal copper/zinc SOD3 (CSD3), and chloroplastic iron SOD3 (FSD3), but no other SODs. MSD1 was inhibited by up to 90% but CSD3 and FSD3 only by a maximum of 30%. Down-regulation of these SOD isoforms correlated with tyrosine (Tyr) nitration and both could be prevented by the peroxynitrite scavenger urate. Site-directed mutagenesis revealed that-amongst the 10 Tyr residues present in MSD1-Tyr63 was the main target responsible for nitration and inactivation of the enzyme. Tyr63 is located nearby the active centre at a distance of only 5.26 Å indicating that nitration could affect accessibility of the substrate binding pocket. The corresponding Tyr34 of human manganese SOD is also nitrated, suggesting that this might be an evolutionarily conserved mechanism for regulation of manganese SODs.
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