Evidence map›Paper›PMID 25428912›Full record

ArticleOncotarget2014

Reduced miR-126 expression facilitates angiogenesis of gastric cancer through its regulation on VEGF-A.

Hongxia Chen, Lingmin Li, Shaojun Wang, Yupeng Lei, Qi Ge, Nonghua Lv, Xiaodong Zhou, Changyan Chen

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed
6.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 130 citations in OpenAlex.

  1. Review
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  10. The regulation roles of miRNAs in Helicobacter pylori infection.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2023
    Review
  11. Review
  12. Review
  13. Angioregulatory microRNAs in breast cancerJournal of advanced research · 2022
    Review
  14. Article
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  16. Review
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  20. Article

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Hongxia ChenDepartment of Gynaecology and Obstetrics, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Lingmin LiDepartment of Gastroenterology, General Hospital of Jinan Military Command, Jinan, China.
Shaojun WangDepartment of Ophthalmology, Affiliated Hospital of Academy of Military Medical Sciences, Beijing, China.
Yupeng LeiDepartment of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Qi GeDepartment of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Nonghua LvDepartment of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Xiaodong ZhouDepartment of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Changyan ChenDepartment of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, China. Center for Drug Discovery, Northeastern University, Boston, USA.
Nanchang University · CNAcademy of Military Medical Sciences · CNFirst Affiliated Hospital of Nanchang University · CNGeneral Hospital of Jinan Military Command · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

miR-126 is an endothelial-specific microRNA essential for governing vascular integrity and angiogenesis. Its role in tumor angiogenesis of gastric cancer (GC) is unclear. This study aimed at determining the role of miR-126 in GC angiogenesis. Down-regulation of miR-126 was found to inversely correlate with an increased microvessel density (MVD) and vascular endothelial growth factor A (VEGF-A) expression in gastric cancer tissues. Bioinformatics analysis and luciferase reporter assay revealed that miR-126 directly targeted the 3'-untranslated region (3'-UTR) of VEGF-A mRNA. In addition, the restoration of miR-126 expression by lentivirus-miR-126 (Lenti-miR-126) transfection obviously reduced the expression of VEGF-A and the activition of its downstream genes, Akt, mTOR and Erk1/2 in gastric cancer cell lines SGC-7901, MKN-28 and MKN-45. In contrast, the down-regulation of miR-126 expression by lentivirus-anti-miR-126 (Lenti-anti-miR-126) transfection obviously up-regulated the expression of VEGF-A and its downstream signaling pathways. In vivo xenograft mice model experiments clarified the down-regulation of VEGF-A and MVD as well as inhibition of tumor growth by up-regulation of miR-126. Overall, the results from our study suggested that miR-126 could suppress tumor growth and tumor angiogenesis of GC through VEGF-A signaling, and it is a novel potential therapeutic target for GC.

Indexed as

AdenocarcinomaAnimalsBlotting, WesternCell Line, TumorDown-RegulationFemaleGene Expression Regulation, NeoplasticHeterograftsHumansImmunohistochemistryMaleMiceMice, Inbred BALB CMice, NudeMicroRNAsNeovascularization, PathologicMicroRNAsMIRN126 microRNA, humanVascular Endothelial Growth Factor AVEGFA protein, human

Identifiers

PMID25428912
PMCPMC4322979
OpenAlexW1942806190

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.