ArticleDNA research : an international journal for rapid publication of reports on genes and genomes2015
Identification of additive, dominant, and epistatic variation conferred by key genes in cellulose biosynthesis pathway in Populus tomentosa†.
Article in DNA research : an international journal for rapid publication of reports on genes and genomes, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Identification of miR171a-International journal of molecular sciences · 2025Article
- Natural variants ofScience advances · 2025Article
- Natural variation in PtobZIP18 confers the trade-off between stem growth and drought tolerance in Populus.Plant biotechnology journal · 2025Article
- Harnessing tree-ring phenotypes to disentangle gene by environment interactions and their climate dependencies in a circum-Mediterranean pine.Annals of botany · 2022Article
- Transcriptome and association mapping revealed functional genes respond to drought stress inFrontiers in plant science · 2022Article
- Genetic Architecture and Genome-Wide Adaptive Signatures Underlying Stem Lenticel Traits inInternational journal of molecular sciences · 2021Article
- Genome-Wide Analysis of Coding and Non-coding RNA Reveals a Conserved miR164-NAC-mRNA Regulatory Pathway for Disease Defense inFrontiers in genetics · 2021Article
- Article
- Genetic interactions among Pto-miR319 family members and their targets influence growth and wood properties in Populus tomentosa.Molecular genetics and genomics : MGG · 2020Article
- SNPeffect: identifying functional roles of SNPs using metabolic networks.The Plant journal : for cell and molecular biology · 2020Article
- Genetic dissection of the gene coexpression network underlying photosynthesis in Populus.Plant biotechnology journal · 2020Article
- Prime Editing Technology and Its Prospects for Future Applications in Plant Biology Research.Biodesign research · 2020Review
- Genome-wide association study identified novel candidate loci affecting wood formation in Norway spruce.The Plant journal : for cell and molecular biology · 2019Article
- Genetic architecture underlying the lignin biosynthesis pathway involves noncoding RNAs and transcription factors for growth and wood properties in Populus.Plant biotechnology journal · 2019Article
- Genome Wide Associations of Growth, Phenology, and Plasticity Traits in Willow [Frontiers in plant science · 2019Article
- Genome-Wide Association Studies to Improve Wood Properties: Challenges and Prospects.Frontiers in plant science · 2018Review
- Article
- Comparing GWAS Results of Complex Traits Using Full Genetic Model and Additive Models for Revealing Genetic Architecture.Scientific reports · 2017Article
- Allelic Interactions amongFrontiers in plant science · 2017Article
- Dissection of Insertion-Deletion Variants within Differentially Expressed Genes Involved in Wood Formation inFrontiers in plant science · 2017Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Economically important traits in many species generally show polygenic, quantitative inheritance. The components of genetic variation (additive, dominant and epistatic effects) of these traits conferred by multiple genes in shared biological pathways remain to be defined. Here, we investigated 11 full-length genes in cellulose biosynthesis, on 10 growth and wood-property traits, within a population of 460 unrelated Populus tomentosa individuals, via multi-gene association. To validate positive associations, we conducted single-marker analysis in a linkage population of 1,200 individuals. We identified 118, 121, and 43 associations (P< 0.01) corresponding to additive, dominant, and epistatic effects, respectively, with low to moderate proportions of phenotypic variance (R(2)). Epistatic interaction models uncovered a combination of three non-synonymous sites from three unique genes, representing a significant epistasis for diameter at breast height and stem volume. Single-marker analysis validated 61 associations (false discovery rate, Q ≤ 0.10), representing 38 SNPs from nine genes, and its average effect (R(2) = 3.8%) nearly 2-fold higher than that identified with multi-gene association, suggesting that multi-gene association can capture smaller individual variants. Moreover, a structural gene-gene network based on tissue-specific transcript abundances provides a better understanding of the multi-gene pathway affecting tree growth and lignocellulose biosynthesis. Our study highlights the importance of pathway-based multiple gene associations to uncover the nature of genetic variance for quantitative traits and may drive novel progress in molecular breeding.
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