ArticleMolecular genetics and genomics : MGG2015
Identification of 4438 novel lincRNAs involved in mouse pre-implantation embryonic development.
Article in Molecular genetics and genomics : MGG, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 24 citations in OpenAlex.
- Article
- Long non-coding RNA ESCCAL-1/miR-590/LRP6 signaling pathway participates in the progression of esophageal squamous cell carcinoma.Cancer medicine · 2023Article
- Mammary epithelial cell transcriptome reveals potential roles of lncRNAs in regulating milk synthesis pathways in Jersey and Kashmiri cattle.BMC genomics · 2022Article
- Comparison of lncRNA Expression in the Uterus between Periods of Embryo Implantation and Labor in Mice.Animals : an open access journal from MDPI · 2022Article
- Identification and Characterization of lncRNAs Related to the Muscle Growth and Development of Japanese Flounder (Frontiers in genetics · 2020Article
- Identification and characterization of pineapple leaf lncRNAs in crassulacean acid metabolism (CAM) photosynthesis pathway.Scientific reports · 2019Article
- Transcriptome Analysis Reveals the Effect of Long Intergenic Noncoding RNAs on Pig Muscle Growth and Fat Deposition.BioMed research international · 2019Article
- Filtered reproductive long non-coding RNAs by genome-wide analyses of goat ovary at different estrus periods.BMC genomics · 2018Article
- Identification of transposons near predicted lncRNA and mRNA pools of Prunus mume using an integrative transposable element database constructed from Rosaceae plant genomes.Molecular genetics and genomics : MGG · 2018Article
- Long non-coding RNAs potentially function synergistically in the cellular reprogramming of SCNT embryos.BMC genomics · 2018Article
- Dynamics of the epigenetic landscape during the maternal-to-zygotic transition.Nature reviews. Molecular cell biology · 2018Review
- Identification of long non-coding RNAs in the immature and mature rat anterior pituitary.Scientific reports · 2017Article
- Single cell transcriptomics of noncoding RNAs and their cell-specificity.Wiley interdisciplinary reviews. RNA · 2017Review
- Genome-wide analysis and functional prediction of long non-coding RNAs in mouse uterus during the implantation window.Oncotarget · 2017Article
- Transcriptome analysis reveals long intergenic non-coding RNAs involved in skeletal muscle growth and development in pig.Scientific reports · 2017Article
- Identification and functional analysis of long intergenic noncoding RNA genes in porcine pre-implantation embryonic development.Scientific reports · 2016Article
- Computational identification of putative lincRNAs in mouse embryonic stem cell.Scientific reports · 2016Article
- lncScore: alignment-free identification of long noncoding RNA from assembled novel transcripts.Scientific reports · 2016Article
- Genome-wide identification and characterization of long non-coding RNAs in developmental skeletal muscle of fetal goat.BMC genomics · 2016Article
- Genome-wide identification and characterization of long intergenic noncoding RNAs and their potential association with larval development in the Pacific oyster.Scientific reports · 2016Article
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Long intergenic non-coding RNAs (lincRNAs) as a key group of non-coding RNAs have gained substantial attention. Though lincRNAs have been systematically explored in various mouse tissues and cell lines, large-scale identification of lincRNAs in mouse pre-implantation embryonic development (PED) process has not be documented previously. Therefore, it is important to identify and characterize novel lincRNAs that may be involved in PED. In this paper, we performed transcriptome assembly based on published single-cell RNA-seq data during mouse PED and identified 4,438 putative lincRNAs. Combining these with Ensembl lincRNAs, we established a reference catalog of 5,808 transcribed lincRNAs in PED. We then systematically analyzed the lincRNAs in this reference catalog and revealed that the identified novel PED lincRNAs are generally comparable with known Ensembl lincRNAs in genomic aspects. In addition, the global expression patterns can be separated by zygote first cleavage division in clustering analysis and we further identified and analyzed differentially expressed lincRNAs involved in this process. The expression of lincRNAs involved in the process is negatively correlated with promoter methylation in trend. The identified lincRNAs involved in zygote first cleavage division could have important roles in mouse early embryonic development and need further functional studies. Altogether, a novel reference catalog of mouse PED lincRNAs is provided and characterized, which would be a valuable resource for further functional analyses and may help elucidate the pre-implantation regulatory mechanism.
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