Trial reportMedical oncology (Northwood, London, England)2015
Iodine-125 brachytherapy improved overall survival of patients with inoperable stage III/IV non-small cell lung cancer versus the conventional radiotherapy.
Trial report in Medical oncology (Northwood, London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 48 citations in OpenAlex.
- Percutaneous implantation of (125)iodine seeds for treatment of portal vein tumor thrombosis in hepatocellular carcinoma.Medical oncology (Northwood, London, England) · 2015Trial
- Local efficacy and safety of CT-guided Iodine-125 seed implantation in the treatment of recurrent malignant tumors: a retrospective study.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Article
- I-125 brachytherapy for early-stage non-small cell lung cancer.Chinese medical journal pulmonary and critical care medicine · 2025Review
- Article
- Efficacy and safety of immune checkpoint inhibitors combined with iodine-125 seed implantation in driver gene-negative non-small cell lung cancer: a retrospective cohort study.Journal of thoracic disease · 2025Article
- Comparative safety and efficacy of single-agent chemotherapy combined with microwave ablation versus radioactive seed brachytherapy in elderly patients with advanced NSCLC: a ten-year retrospective study.American journal of cancer research · 2025Article
- Clinical efficacy analysis of radioactiveJournal of contemporary brachytherapy · 2023Article
- Review
- Iodine-125 seeds insertion with trans-arterial chemical infusion for advanced lung cancer: a meta-analysis.Journal of contemporary brachytherapy · 2022Review
- Dosimetry verification of three-dimensional printed polylactic acid template-guided precisionJournal of applied clinical medical physics · 2021Article
- Combined effects of low-dose gambogic acid and NaIOncology letters · 2021Article
- Stereotactic Ablative Brachytherapy: Recent Advances in Optimization of Radiobiological Cancer Therapy.Cancers · 2021Review
- Radioactive Iodine-125 in Tumor Therapy: Advances and Future Directions.Frontiers in oncology · 2021Review
- Efficacy and Safety Aiming at the Combined-Modality Therapy of External Beam Radiotherapy (40Gy) and Iodine-125 Seed Implantation for Locally Advanced NSCLC in the Elderly.Cancer management and research · 2021Article
- Efficacy and safety of CT-guidedOncology letters · 2020Article
- Oligorecurrence Non-small Cell Lung Cancer After Failure of First-Line Chemotherapy: Computed Tomography-GuidedFrontiers in oncology · 2020Article
- Article
- Safety and efficacy of CT-guided radioactive iodine-125 seed implantation assisted by a 3D printing template for the treatment of thoracic malignancies.Journal of cancer research and clinical oncology · 2020Article
- Radiation-related Adverse Effects of CT-guided Implantation ofScientific reports · 2019Article
- How many timesJournal of contemporary brachytherapy · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study compared the efficacy of iodine-125 seed brachytherapy versus the conventional radiotherapy in patients with non-resectable stage III/IV non-small cell lung cancer. A total of 71 patients with inoperable advanced stages of lung cancer with tumor size ranging 5-10 cm were randomly assigned into two groups: Group A received the regional iodine-125 implantation (n = 35), and Group B received the conventional radiotherapy (n = 36). The isodose curves were obtained by the treatment planning system for patients in Group A. Postoperative tumor size, clinical symptoms, and quality of life were then assessed. The overall response rate (complete response + partial response) was 88 and 59 % in Group A and Group B, respectively. Moreover, patients receiving iodine-125 implantation had higher one- or two-year survival rates than those patients receiving radiation therapy (P < 0.05). For patients with a large tumor, iodine-125 implantation significantly ameliorated the clinical symptoms and improved quality of life compared with the conventional radiotherapy and chemotherapy. Iodine-125 implantation treatment was more effective to control inoperable, large lung cancer and improved overall survival and quality of life compared with the conventional radiotherapy and chemotherapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.