Evidence map›Paper›PMID 25428363›Full record

ArticleNucleic acids research2015

The BioGRID interaction database: 2015 update.

Andrew Chatr-Aryamontri, Bobby-Joe Breitkreutz, Rose Oughtred, Lorrie Boucher, Sven Heinicke, Daici Chen, Chris Stark, Ashton Breitkreutz, Nadine Kolas, Lara O'Donnell and 12 more

Abstract read
In one paragraph

Article in Nucleic acids research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 505 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
505citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

505 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Multi-omics to study chronic respiratory diseases and viral infections.European respiratory review : an official journal of the European Respiratory Society · 2026
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  12. A disease-specific convergence of host and Epstein-Barr virus genetics in multiple sclerosis.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
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  15. Article
  16. Article
  17. Article
  18. Non-Coding RNAs Extended Omnigenic Module of Cancers.Entropy (Basel, Switzerland) · 2024
    Article
  19. Article
  20. Article

445 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Andrew Chatr-AryamontriInstitute for Research in Immunology and Cancer, Université de Montréal, Montréal, Quebec H3C 3J7, Canada.
Bobby-Joe BreitkreutzThe Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
Rose OughtredLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.
Lorrie BoucherThe Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
Sven HeinickeLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.
Daici ChenInstitute for Research in Immunology and Cancer, Université de Montréal, Montréal, Quebec H3C 3J7, Canada.
Chris StarkThe Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
Ashton BreitkreutzThe Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
Nadine KolasThe Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
Lara O'DonnellThe Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
Teresa RegulyThe Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
Julie NixonSchool of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JR, UK.
Lindsay RamageSchool of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JR, UK.
Andrew WinterSchool of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JR, UK.
Adnane SellamCentre Hospitalier de l'Université Laval (CHUL), Québec, Québec G1V 4G2, Canada.
Christie ChangLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.
Jodi HirschmanLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.
Chandra TheesfeldLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.
Jennifer RustLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.
Michael S LivstoneLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.
Kara DolinskiLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.
Mike TyersInstitute for Research in Immunology and Cancer, Université de Montréal, Montréal, Quebec H3C 3J7, Canada The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JR, UK md.tyers@umontreal.ca.

Funding

Pilot Study: POPULATION PHARMACOLOGYU54HL117798 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI GROSSER, TILO · 2012 to 2016
$18.5M
BioGRID: An open resource for biological interactions and network analysisR01OD010929 · OD · SINAI HEALTH SYSTEM · PI KARA DOLINSKI, Mike Tyers · 2012 to 2026
$13.9M
Systematic data curation and integration to link models of human diseaseR24OD011194 · OD · PRINCETON UNIVERSITY · PI DOLINSKI, KARA · 2012 to 2014
$1.9M
Biotechnology and Biological Sciences Research Council BB/F010486/1NHLBI NIH HHS U54 HL117798NHLBI NIH HHS U54HL117798NIH HHS R01 OD010929NIH HHS R01OD010929NIH HHS R24OD011194
6 · The paper itself

Abstract

The Biological General Repository for Interaction Datasets (BioGRID: http://thebiogrid.org) is an open access database that houses genetic and protein interactions curated from the primary biomedical literature for all major model organism species and humans. As of September 2014, the BioGRID contains 749,912 interactions as drawn from 43,149 publications that represent 30 model organisms. This interaction count represents a 50% increase compared to our previous 2013 BioGRID update. BioGRID data are freely distributed through partner model organism databases and meta-databases and are directly downloadable in a variety of formats. In addition to general curation of the published literature for the major model species, BioGRID undertakes themed curation projects in areas of particular relevance for biomedical sciences, such as the ubiquitin-proteasome system and various human disease-associated interaction networks. BioGRID curation is coordinated through an Interaction Management System (IMS) that facilitates the compilation interaction records through structured evidence codes, phenotype ontologies, and gene annotation. The BioGRID architecture has been improved in order to support a broader range of interaction and post-translational modification types, to allow the representation of more complex multi-gene/protein interactions, to account for cellular phenotypes through structured ontologies, to expedite curation through semi-automated text-mining approaches, and to enhance curation quality control.

Indexed as

Databases, GeneticGene Regulatory NetworksProtein Interaction MappingArachidonic AcidDiseaseHumansInternetArachidonic Acid

Identifiers

PMID25428363
PMCPMC4383984

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.