ReviewMedical principles and practice : international journal of the Kuwait University, Health Science Centre2015
Recurrent spontaneous miscarriage is still a challenging diagnostic and therapeutic quagmire.
Review in Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 86 citations in OpenAlex.
- Efficacy of therapeutic interventions for idiopathic recurrent pregnancy loss: a systematic review and network meta-analysis.Frontiers in medicine · 2025Pooled it
- Association between gene polymorphism of folate metabolism and recurrent spontaneous abortion in Asia: A Meta-analysis.Medicine · 2020Pooled it
- Quantitative proteomic profiling of placental extracellular vesicles in recurrent pregnancy loss reveals their role in feto-maternal crosstalk.BMC pregnancy and childbirth · 2026Article
- Associations of four insulin resistance indicators with subsequent pregnancy outcomes in women with recurrent pregnancy loss.Frontiers in endocrinology · 2026Article
- Burden, causes, and treatment approaches of recurrent pregnancy loss: a scoping review.The Pan African medical journal · 2025Article
- The circRNA Landscape in Recurrent Pregnacy Loss (RPL): A Comparison of Four Reproductive Tissues.International journal of molecular sciences · 2024Article
- Arsenic Methyltransferase and Apolipoprotein E Polymorphism in Pregnant Women Exposed to Inorganic Arsenic in Drinking Water in Western Romania.International journal of molecular sciences · 2024Article
- Metformin may induce immunologic tolerance at the maternal-foetal interface in early human pregnancy.American journal of translational research · 2023Article
- Insight of Autophagy in Spontaneous Miscarriage.International journal of biological sciences · 2022Review
- Evaluating the Association Between Genetic Polymorphisms Related to Homocysteine Metabolism and Unexplained Recurrent Pregnancy Loss in Women.The application of clinical genetics · 2022Article
- Association of Polymorphisms inDisease markers · 2022Article
- Association between the rs3802201 polymorphism of the lncRNA MIR2052HG gene and the risk of recurrent miscarriage in a Southern Chinese population.Journal of clinical laboratory analysis · 2022Article
- Analysis of parental abnormal chromosomal karyotype and subsequent live births in Chinese couples with recurrent pregnancy loss.Scientific reports · 2021Article
- Evaluating the Clinical Risk Factors Associated With Miscarriages in Women in Karachi, Pakistan.Cureus · 2021Article
- Comparative clinical genetic testing in spontaneous miscarriage: Insights from a study in Southern Chinese women.Journal of cellular and molecular medicine · 2021Article
- INO80 participates in the pathogenesis of recurrent miscarriage by epigenetically regulating trophoblast migration and invasion.Journal of cellular and molecular medicine · 2021Article
- Cytogenetic signatures of recurrent pregnancy losses.Prenatal diagnosis · 2021Article
- The Immune Atlas of Human Deciduas With Unexplained Recurrent Pregnancy Loss.Frontiers in immunology · 2021Article
- The lncRNAJournal of inflammation research · 2021Article
- Association between the TOX3 rs3803662 C>T polymorphism and recurrent miscarriage in a southern Chinese population.Journal of clinical laboratory analysis · 2019Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recurrent spontaneous miscarriage (RSM), affecting 1-2% of women of reproductive age seeking pregnancy, has been a clinical quagmire and a formidable challenge for the treating physician. There are many areas of controversy in the definition, aetiology, investigations and treatment of RSM. This review will address the many factors involved in the aetiology of RSM which is multifactorial in many patients, with antiphospholipid syndrome (APS) being the most recognized aetiological factor. There is no identifiable cause in about 40-60% of these patients, in which case the condition is classified as idiopathic or unexplained RSM. The RSM investigations are extensive and should be undertaken in dedicated, specialized, well-equipped clinics/centres where services are provided by trained specialists. The challenges faced by the treating physician are even more overwhelming regarding the decision of what should be the most appropriate therapy offered to patients with RSM. Our review will cover the diverse modalities of therapy available including the role of preimplantation genetic testing using recent microarray technology, such as single nucleotide polymorphism and comparative genomic hybridization, as well as preimplantation genetic diagnosis; the greatest emphasis will be on the treatment of APS, and there will be important comments on the management of patients presenting with idiopathic RSM. The controversial areas of the role of natural killer cells in RSM, the varied modalities in the management of idiopathic RSM and the need for better-planned studies will be covered as well.
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