ArticleJournal of clinical microbiology2015
Characteristics of emerging human-pathogenic Escherichia coli O26:H11 strains isolated in France between 2010 and 2013 and carrying the stx2d gene only.
Article in Journal of clinical microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Pathogenic potential and phylogenomic analysis ofMicrobial genomics · 2026Article
- An outbreak of Shiga toxin-producingEpidemiology and infection · 2026Article
- Enhancing detection of STEC in the meat industry: insights into virulence of priority STEC.Frontiers in microbiology · 2025Article
- Phylogenetic relationship and virulence composition ofFrontiers in microbiology · 2023Article
- Large-Scale Phylogenetic Analysis Reveals a New Genetic Clade among Escherichia coli O26 Strains.Microbiology spectrum · 2022Article
- Population Analysis of O26 Shiga Toxin-ProducingFrontiers in cellular and infection microbiology · 2022Article
- Epidemiology and genomic analysis of Shiga toxin-producingJournal of medical microbiology · 2021Article
- Low-Temperature Virus vB_EcoM_VR26 Shows Potential in Biocontrol of STEC O26:H11.Foods (Basel, Switzerland) · 2021Article
- Switching Shiga Toxin (Stx) Type from Stx2d to Stx2a but Not Stx2c Alters Virulence of Stx-ProducingToxins · 2021Article
- Molecular characteristics ofEmerging microbes & infections · 2020Article
- Preliminary data on the antimicrobial effect ofItalian journal of food safety · 2020Article
- Virulence Profiling and Molecular Typing of Shiga Toxin-ProducingMicroorganisms · 2020Article
- Bimodal Response to Shiga Toxin 2 Subtypes Results from Relatively Weak Binding to the Target Cell.Infection and immunity · 2019Article
- Virulence Genes, Shiga Toxin Subtypes, Serogroups, and Clonal Relationship of Shiga Toxin-ProducingAnimals : an open access journal from MDPI · 2019Article
- Phylogenetic context of Shiga toxin-producingMicrobial genomics · 2019Article
- Use of Genomics to Investigate Historical Importation of Shiga Toxin-Producing Escherichia coli Serogroup O26 and Nontoxigenic Variants into New Zealand.Emerging infectious diseases · 2019Article
- Whole genome sequencing based typing and characterisation of Shiga-toxin producingItalian journal of food safety · 2018Article
- Presence of Shiga Toxin-ProducingMicroorganisms · 2018Article
- Attack of the clones: whole genome-based characterization of two closely related enterohemorrhagic Escherichia coli O26 epidemic lineages.BMC genomics · 2018Article
- Variability in CharacterizingMicroorganisms · 2018Article
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5 authors.
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Abstract
Strains of Escherichia coli O26:H11 that were positive for stx2 alone (n = 23), which were not epidemiologically related or part of an outbreak, were isolated from pediatric patients in France between 2010 and 2013. We were interested in comparing these strains with the new highly virulent stx2a-positive E. coli O26 clone sequence type 29 (ST29) that has emerged recently in Europe, and we tested them by multilocus sequence typing (MLST), stx2 subtyping, clustered regularly interspaced short palindromic repeat (CRISPR) sequencing, and plasmid (ehxA, katP, espP, and etpD) and chromosomal (Z2098, espK, and espV) virulence gene profiling. We showed that 16 of the 23 strains appeared to correspond to this new clone, but the characteristics of 12 strains differed significantly from the previously described characteristics, with negative results for both plasmid and chromosomal genetic markers. These 12 strains exhibited a ST29 genotype and related CRISPR arrays (CRISPR2a alleles 67 or 71), suggesting that they evolved in a common environment. This finding was corroborated by the presence of stx2d in 7 of the 12 ST29 strains. This is the first time that E. coli O26:H11 carrying stx2d has been isolated from humans. This is additional evidence of the continuing evolution of virulent Shiga toxin-producing E. coli (STEC) O26 strains. A new O26:H11 CRISPR PCR assay, SP_O26_E, has been developed for detection of these 12 particular ST29 strains of E. coli O26:H11. This test is useful to better characterize the stx2-positive O26:H11 clinical isolates, which are associated with severe clinical outcomes such as bloody diarrhea and hemolytic uremic syndrome.
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