Evidence map›Paper›PMID 25427878›Full record

ArticleMaternal and child health journal2015

Does pet-keeping modify the association of delivery mode with offspring body size?

Andrea E Cassidy-Bushrow, Ganesa Wegienka, Suzanne Havstad, Albert M Levin, Susan V Lynch, Dennis R Ownby, Andrew G Rundle, Kimberley J Woodcroft, Edward M Zoratti, Christine Cole Johnson

Abstract read
In one paragraph

Article in Maternal and child health journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Prenatal antimicrobial use and early-childhood body mass index.International journal of obesity (2005) · 2018
    Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Andrea E Cassidy-BushrowDepartment of Public Health Sciences, Henry Ford Hospital, 1 Ford Place, 5C, Detroit, MI, 48202, USA, acassid1@hfhs.org.
Ganesa Wegienka
Suzanne Havstad
Albert M Levin
Susan V Lynch
Dennis R Ownby
Andrew G Rundle
Kimberley J Woodcroft
Edward M Zoratti
Christine Cole Johnson

Funding

The Effect of Dog-Keeping and the Intestinal Microbiota on Immune DevelopmentP01AI089473 · NIAID · HENRY FORD HEALTH SYSTEM · PI OWNBY, DENNIS R · 2012 to 2024
$25.7M
Early Environmental Hygiene and Pediatric AtopyR01AI050681 · NIAID · HENRY FORD HEALTH SYSTEM · PI JOHNSON, CHRISTINE C · 2002 to 2006
$2.9M
EARLY LIFE VITAMIN D, RACIAL DISPARITIES, AND WHEEZINGR01HL113010 · NHLBI · HENRY FORD HEALTH SYSTEM · PI WEGIENKA, GANESA REBECCA · 2012 to 2014
$1.2M
NHLBI NIH HHS R01 HL113010NIAID NIH HHS P01 AI089473NIAID NIH HHS R01 AI050681
6 · The paper itself

Abstract

Caesarean-section (CS) delivery increases risk of childhood obesity, and is associated with a distinct early-life gut microbiome, which may contribute to obesity. Household pets may alter human gut microbiome composition. We examined if pet-keeping modified the association of CS with obesity at age 2 years in 639 Wayne County Health, Environment, Allergy and Asthma Longitudinal Study birth cohort participants. Pet-keeping was defined as having a dog or cat (indoors ≥1 h/day) at child age 2 years. We used logistic regression to test for an interaction between CS and pet-keeping with obesity (BMI ≥ 95th percentile) at age 2 years, adjusted for maternal obesity. A total of 328 (51.3 %) children were male; 367 (57.4 %) were African American; 228 (35.7 %) were born by CS; and 55 (8.6 %) were obese. After adjusting for maternal obesity, CS-born children had a non-significant (P = 0.25) but elevated 1.4 (95 % CI 0.8, 2.5) higher odds of obesity compared to those born vaginally. There was evidence of effect modification between current pet-keeping and delivery mode with obesity at age 2 years (interaction P = 0.054). Compared to children born vaginally without a pet currently in the home, children born via CS without a pet currently in the home had a statistically significant (P = 0.043) higher odds (odds ratio 2.00; 95 % CI 1.02, 3.93) of being obese at age 2 years. Pets modified the CS-BMI relationship; whether the underlying mechanism is through effects on environmental or gut microbiome requires specific investigation.

Indexed as

CatsDogsPetsAdultAnimalsBody SizeCesarean SectionChild, PreschoolDelivery, ObstetricFemaleHumansMaleMiddle AgedPediatric ObesityPregnancyRisk Factors

Identifiers

PMID25427878
PMCPMC4446256

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.