Evidence map›Paper›PMID 25427547›Full record

ArticleAIDS research and human retroviruses2015

Exploring the social meaning of curing HIV: a qualitative study of people who inject drugs in Guangzhou, China.

Carissa E Chu, Feng Wu, Xi He, Qingyan Ma, Yu Cheng, Weiping Cai, Paul Volberding, Joseph D Tucker

Abstract read
In one paragraph

Article in AIDS research and human retroviruses, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Carissa E Chu1 Department of Medicine, School of Medicine, University of California San Francisco , San Francisco, California.
Feng Wu
Xi He
Qingyan Ma
Yu Cheng
Weiping Cai
Paul Volberding
Joseph D Tucker

Funding

Unintended and Intended Implications of HIV Cure: A Social and Ethical AnalysisR01AI108366 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RENNIE, STUART, TUCKER, JOSEPH DAVID · 2013 to 2017
$2.9M
UNC-South China STD Research Training CenterD43TW009532 · FIC · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COHEN, MYRON SCOTT, TUCKER, JOSEPH DAVID · 2013 to 2017
$1.3M
FIC NIH HHS D43 TW009532NIAID NIH HHS R01 AI108366PHS HHS NIAID P30-AI50410PHS HHS NIAID R01A108366-01
6 · The paper itself

Abstract

Our objective was to explore the social meaning of HIV and perceptions of an HIV cure among people who inject drugs (PWID) in Guangzhou, China, which speaks to ethical and resource challenges to development in this field. We conducted a qualitative research study using in-depth interviews. We analyzed interview transcripts from 29 PWID, eight physicians, and three social workers from an outpatient HIV clinic and two methadone maintenance treatment centers. The social meaning of HIV infection and perceptions of an HIV cure reflected patients' relationships with society, health systems, and physicians. First, HIV infection decreased perceived social worth and disrupted peer relationships. The possibility of being cured renewed patient hope for regaining physical well-being and achieving social mobility. However, the existence of a cure may not alter the HIV-related stigma due to its association with stigmatized behaviors and marginalized groups. Second, although stigma was a significant barrier to engagement in health care, hope for a cure may outweigh fears of stigma and enhance linkage to HIV testing and treatment as well as methadone services. A cure may exacerbate perceived health disparities if inaccessible to key affected populations such as PWID. The social implications of an HIV cure among this key affected population may inform the design and implementation of cure clinical trials. Careful management of patient expectations, focusing research on key affected populations, expanding HIV testing and treatment systems, improving access to harm reduction programs, and ensuring post-trial access are important considerations for HIV cure research.

Indexed as

Psychological DistanceSocial StigmaAdultAnti-HIV AgentsChinaData CollectionFemaleHIV InfectionsHumansMaleMethadoneMiddle AgedSocial MarginalizationSubstance Abuse, IntravenousAnti-HIV AgentsMethadone

Identifiers

PMID25427547
PMCPMC4287130

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.