ReviewBiomolecules2014
The immunoglobulins of cold-blooded vertebrates.
Review in Biomolecules, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 66 citations in OpenAlex.
- Reconstructed amphibian heavy-chain constant regions support a mosaic origin of IgXA with IgY-like CH1-CH2, an intermediate CH3, and an IgM-like CH4.Immunogenetics · 2026Article
- Immunoglobulin genetics of a model squamate reptile, Tiliqua rugosa.Immunogenetics · 2025Article
- Chimeric Immunoglobulin and human Immunoglobulin M structures provide insights on joining-chain independent assembly and function.bioRxiv : the preprint server for biology · 2025Article
- The function of antibodies.Immunological reviews · 2024Review
- Squamate reptiles may have compensated for the lack of γδTCR with a duplication of the TRB locus.Frontiers in immunology · 2024Article
- Rejection of Lepeophtheirus salmonis driven in part by chitin sensing is not impacted by seawater acclimitization in Coho salmon (Oncorhynchus kisutch).Scientific reports · 2023Article
- 450 million years in the making: mapping the evolutionary foundations of germinal centers.Frontiers in immunology · 2023Review
- Gene prediction in the immunoglobulin loci.Genome research · 2022Article
- On the relationship between extant innate immune receptors and the evolutionary origins of jawed vertebrate adaptive immunity.Immunogenetics · 2022Review
- Comparative Aspects of Immunoglobulin Gene Rearrangement Arrays in Different Species.Frontiers in immunology · 2022Review
- Kinetics of Parasite-Specific Antibody and B-Cell-Associated Gene Expression in Brown Trout,Biology · 2021Article
- Immunoglobulins in teleosts.Immunogenetics · 2021Review
- Structure, Function, and Therapeutic Use of IgM Antibodies.Antibodies (Basel, Switzerland) · 2020Review
- Early life disruption of the microbiota affects organ development and cytokine gene expression in threespine stickleback.Integrative and comparative biology · 2020Article
- The proteomics of roadside hawk (Rupornis magnirostris), broad-snouted caiman (Caiman latirostris) and loggerhead sea turtle (Caretta caretta) tears.BMC veterinary research · 2020Article
- A portrait of the immune response to proliferative kidney disease (PKD) in rainbow trout.Parasite immunology · 2020Review
- Intestinal B cells in the red-eared slider turtle, Trachemys scripta: Anatomical distribution and implications for ecological interactions with pathogenic microbes.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2019Article
- The Costs of Living Together: Immune Responses to the Microbiota and Chronic Gut Inflammation.Applied and environmental microbiology · 2019Review
- A Comparison of the Innate and Adaptive Immune Systems in Cartilaginous Fish, Ray-Finned Fish, and Lobe-Finned Fish.Frontiers in immunology · 2019Review
- Haptoglobin Is a Divergent MASP Family Member That Neofunctionalized To Recycle Hemoglobin via CD163 in Mammals.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although lymphocyte-like cells secreting somatically-recombining receptors have been identified in the jawless fishes (hagfish and lamprey), the cartilaginous fishes (sharks, skates, rays and chimaera) are the most phylogenetically distant group relative to mammals in which bona fide immunoglobulins (Igs) have been found. Studies of the antibodies and humoral immune responses of cartilaginous fishes and other cold-blooded vertebrates (bony fishes, amphibians and reptiles) are not only revealing information about the emergence and roles of the different Ig heavy and light chain isotypes, but also the evolution of specialised adaptive features such as isotype switching, somatic hypermutation and affinity maturation. It is becoming increasingly apparent that while the adaptive immune response in these vertebrate lineages arose a long time ago, it is most definitely not primitive and has evolved to become complex and sophisticated. This review will summarise what is currently known about the immunoglobulins of cold-blooded vertebrates and highlight the differences, and commonalities, between these and more "conventional" mammalian species.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.