ArticlePloS one2014
Cardio-respiratory reference data in 4631 healthy men and women 20-90 years: the HUNT 3 fitness study.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 64 citations in OpenAlex.
- Hippocampal neurochemicals are associated with exercise group and intensity, psychological health, and general cognition in older adults.GeroScience · 2023Trial
- Exercise Intensity and 5-Yr Trajectories in Peak Oxygen Uptake in Older Adults: Analysis from the Generation 100 Study.Medicine and science in sports and exercise · 2026Observational
- Lung function and ventilatory response during high-intensity treadmill walking in adults with cerebral palsy: a cross-sectional study.Journal of rehabilitation medicine · 2026Article
- Functional, molecular, and digital measurements of biological age.The Journal of clinical investigation · 2026Review
- Evaluation of Genetics in the Association Between Cardiorespiratory Fitness and Health: Insights from a Genome-Wide Polygenic Score for Cardiorespiratory Fitness in the FinnGen and HUNT cohorts.Scandinavian journal of medicine & science in sports · 2026Article
- Article
- Polygenic prediction of cardiorespiratory fitness in the Trøndelag health study (HUNT).Scientific reports · 2025Article
- Effects of 5-Year Exercise Training on Cognition in Older Adults: 10-Years Follow-Up from the Generation 100 Study.Sports medicine - open · 2025Article
- Cardiorespiratory fitness, cardiac morphology and function, and cardiovascular risk factors in long-term breast cancer survivors compared with non-cancer controls.Cardio-oncology (London, England) · 2025Article
- Polygenic Interactions With Environmental Exposures in Blood Pressure Regulation: The HUNT Study.Journal of the American Heart Association · 2024Article
- Is the Ventilatory Efficiency in Endurance Athletes Different?-Findings from the NOODLE Study.Journal of clinical medicine · 2024Article
- Perioperative Exercise Testing in Pregnant and Non-Pregnant Women of Reproductive Age: A Systematic Review.Journal of clinical medicine · 2024Review
- Left atrial to ventricular volume ratio and relation to fitness, cardiovascular risk factors, and diastolic function in healthy individuals: the HUNT Study.European heart journal. Imaging methods and practice · 2024Article
- Associations of polygenic inheritance of physical activity with aerobic fitness, cardiometabolic risk factors and diseases: the HUNT study.European journal of epidemiology · 2023Article
- Respiratory aerosol particle emission and simulated infection risk is greater during indoor endurance than resistance exercise.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- COX7A2L genetic variants determine cardiorespiratory fitness in mice and human.Nature metabolism · 2022Article
- Article
- Aerosol particle emission increases exponentially above moderate exercise intensity resulting in superemission during maximal exercise.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Effects of a taped filter mask on peak power, perceived breathlessness, heart rate, blood lactate and oxygen saturation during a graded exercise test in young healthy adults: a randomized controlled trial.BMC sports science, medicine & rehabilitation · 2022Article
- Do Breast Cancer Patients Manage to Participate in an Outdoor, Tailored, Physical Activity Program during Adjuvant Breast Cancer Treatment, Independent of Health and Socio-Demographic Characteristics?Journal of clinical medicine · 2022Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo provide a large reference material on key cardio-respiratory variables in a healthy population of Norwegian men and women aged 20-90 years.
methodsSub maximal and peak levels of cardio-respiratory variables were measured using cardiopulmonary exercise testing during treadmill running.
resultsThe highest peak ventilation among men (141.9±24.5 L·min-1) and women (92.0±16.5 L·min-1) was observed in the youngest age group (20-29 years, sex differences p<0.001) with an average 7% reduction per decade. The highest tidal volumes were observed in the 30-39 and 40-49 year age groups among men (2.94±0.46 L) and women (2.06±0.32 L) (sex differences p<0.001), with a subsequent average 6% reduction per decade. Ventilatory threshold and respiratory compensation point were observed at approximately 77% and 87% of peak oxygen uptake (VO2peak) among men and women, respectively. The best ventilatory efficiency (EqVCO2Than) was observed in the youngest age group (20-29 years) in both men (26.2±2.8) and woman (27.5±2.7) (sex differences p<0.001) with an average 3% deterioration in ventilatory efficiency per decade.
conclusionThis is the largest European reference material of cardio-respiratory variables in healthy men and women aged 20-90 years, establishing normal values for, and associations between key cardio-respiratory parameters. This will be useful in clinical decision making when evaluating cardiopulmonary health in similar populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.