ArticlePloS one2014
The lineage-specific evolution of aquaporin gene clusters facilitated tetrapod terrestrial adaptation.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
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67 citing papers in PubMed, 145 citations in OpenAlex.
- The unorthodox aquaporin-12L ortholog is essential for oogenesis in the crustacean Artemia franciscana.Bioscience reports · 2026Article
- Chromosome-level reference genome for the common wall gecko (Tarentola mauritanica) enables comparative and functional studies in geckos.G3 (Bethesda, Md.) · 2026Article
- Chromosomal Replication, Translocation and Recombination as Putative Events in the Diversification of VertebrateInternational journal of molecular sciences · 2026Article
- Genome-wide identification and solute selectivity of aquaporins in the sharpnose sevengill shark, Heptranchias perlo.Physiological reports · 2026Article
- Innovations in Silicon Transport Shaped the Rise of Biosilicification and Skeletal Evolution in Sponges.Molecular biology and evolution · 2026Article
- Localization and Expression of Aquaporin 0 (AQP0/MIP) in the Tissues of the Spiny Dogfish (International journal of molecular sciences · 2026Article
- Genome-Wide Identification and Expression Analysis of the Aquaporin Gene Family in the Qinghai Toad-Headed Agama (Biology · 2025Article
- Loss and Gain of Aqp10 Paralogs With Broad Solute Selectivity in Anguillid Eels.Genome biology and evolution · 2025Article
- Localization and Expression of Aquaporin 1 (AQP1) in the Tissues of the Spiny Dogfish (International journal of molecular sciences · 2025Article
- Early Diversification of Membrane Intrinsic Proteins (MIPs) in Eukaryotes.Genome biology and evolution · 2024Article
- slc26a12-A novel member of the slc26 family, is located in tandem with slc26a2 in coelacanths, amphibians, reptiles, and birds.Physiological reports · 2024Article
- Chromosomal DNA sequences of the Pacific saury genome: versatile resources for fishery science and comparative biology.DNA research : an international journal for rapid publication of reports on genes and genomes · 2024Article
- Evidence That Aquaporin 11 (AQP11) in the Spiny Dogfish (International journal of molecular sciences · 2024Article
- Functional Divergence in Solute Permeability between Ray-Finned Fish-Specific Paralogs of aqp10.Genome biology and evolution · 2024Article
- Ionic regulatory strategies of crabs: the transition from water to land.Frontiers in physiology · 2024Review
- From Homeostasis to Pathology: Decoding the Multifaceted Impact of Aquaporins in the Central Nervous System.International journal of molecular sciences · 2023Review
- Adaptive Selection in the Evolution of Aquaglyceroporins in Mammals.Journal of molecular evolution · 2023Article
- Genome-Wide Identification ofInternational journal of molecular sciences · 2023Article
- Article
- Functional Evolution of Clustered Aquaporin Genes Reveals Insights into the Oceanic Success of Teleost Eggs.Molecular biology and evolution · 2023Article
7 more citing papers are in PubMed but not listed here.
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5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A major physiological barrier for aquatic organisms adapting to terrestrial life is dessication in the aerial environment. This barrier was nevertheless overcome by the Devonian ancestors of extant Tetrapoda, but the origin of specific molecular mechanisms that solved this water problem remains largely unknown. Here we show that an ancient aquaporin gene cluster evolved specifically in the sarcopterygian lineage, and subsequently diverged into paralogous forms of AQP2, -5, or -6 to mediate water conservation in extant Tetrapoda. To determine the origin of these apomorphic genomic traits, we combined aquaporin sequencing from jawless and jawed vertebrates with broad taxon assembly of >2,000 transcripts amongst 131 deuterostome genomes and developed a model based upon Bayesian inference that traces their convergent roots to stem subfamilies in basal Metazoa and Prokaryota. This approach uncovered an unexpected diversity of aquaporins in every lineage investigated, and revealed that the vertebrate superfamily consists of 17 classes of aquaporins (Aqp0 - Aqp16). The oldest orthologs associated with water conservation in modern Tetrapoda are traced to a cluster of three aqp2-like genes in Actinistia that likely arose >500 Ma through duplication of an aqp0-like gene present in a jawless ancestor. In sea lamprey, we show that aqp0 first arose in a protocluster comprised of a novel aqp14 paralog and a fused aqp01 gene. To corroborate these findings, we conducted phylogenetic analyses of five syntenic nuclear receptor subfamilies, which, together with observations of extensive genome rearrangements, support the coincident loss of ancestral aqp2-like orthologs in Actinopterygii. We thus conclude that the divergence of sarcopterygian-specific aquaporin gene clusters was permissive for the evolution of water conservation mechanisms that facilitated tetrapod terrestrial adaptation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.