SynthesisJournal of burn care & research : official publication of the American Burn Association
Albumin in Burn Shock Resuscitation: A Meta-Analysis of Controlled Clinical Studies.
Synthesis in Journal of burn care & research : official publication of the American Burn Association. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Wound, Pressure Ulcer, and Burn Guidelines (2023)-6: Guidelines for the Management of Burns, Third Edition.The Journal of dermatology · 2026Guideline
- Guideline
- Poor methodological quality and reporting standards of systematic reviews in burn care management.International wound journal · 2017Pooled it
- [A prospectively randomized controlled study of the effects of intensive insulin therapy combined with glutamine on nutritional metabolism, inflammatory response, and hemodynamics in severe burn patients].Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns · 2021Trial
- Multi-Organ Failure in Adult Patients Admitted to Intensive Care with Severe Burns-A Retrospective Cohort Study.European burn journal · 2026Article
- From Serum to Surgery: The Significance of Albumin in Preoperative Risk Stratification-An Analysis of 200,015 Plastic Surgery Patients.Aesthetic plastic surgery · 2026Article
- Expanding the Limits of Burn Care: Survival After a 92% Total Body Surface Area Burn.European burn journal · 2025Article
- Characterisation of Fluid Administration in Burn Shock-A Retrospective Cohort Analysis.European burn journal · 2025Article
- Lactate to albumin ratio has limited prognostic value for complications in children under five with burn injuries.Scientific reports · 2025Article
- The impact of Albumin Administration on Mortality and Resuscitation Volume in Burn Resuscitation: A Systematic Review and Meta-Analysis.Bulletin of emergency and trauma · 2025Review
- Microcirculatory depth of focus measurement shows reduction of tissue edema by albumin resuscitation in burn patients.Journal of intensive medicine · 2025Article
- Lower Admission Prealbumin and Albumin Levels in Unhoused Burn Patients Is a Marker for Poorer Outcomes.Journal of burn care & research : official publication of the American Burn Association · 2024Article
- War at Sea: Burn Care Challenges-Past, Present and Future.European burn journal · 2023Review
- Clinical Profile of Children with Burns in a Tertiary Care Hospital.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2023Article
- Burn Resuscitation Practices in North America: Results of the Acute Burn ResUscitation Multicenter Prospective Trial (ABRUPT).Annals of surgery · 2023Observational
- Medical and Surgical Care of Critical Burn Patients: A Comprehensive Review of Current Evidence and Practice.Cureus · 2022Review
- [Use of albumin : State of the art].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2021Review
- Life-threatening skin conditions presenting to critical care.BJA education · 2021Review
- Effect of the infusion ration between frozen plasma and plasma substitutes on the prognosis of adult patients with major burn in shock stage.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2021Article
- [Standards in medical treatment of burns].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Critical appraisal of outcomes after burn shock resuscitation with albumin has previously been restricted to small relatively old randomized trials, some with high risk of bias. Extensive recent data from nonrandomized studies assessing the use of albumin can potentially reduce bias and add precision. The objective of this meta-analysis was to determine the effect of burn shock resuscitation with albumin on mortality and morbidity in adult patients. Randomized and nonrandomized controlled clinical studies evaluating mortality and morbidity in adult patients receiving albumin for burn shock resuscitation were identified by multiple methods, including computer database searches and examination of journal contents and reference lists. Extracted data were quantitatively combined by random-effects meta-analysis. Four randomized and four nonrandomized studies with 688 total adult patients were included. Treatment effects did not differ significantly between the included randomized and nonrandomized studies. Albumin infusion during the first 24 hours showed no significant overall effect on mortality. However, significant statistical heterogeneity was present, which could be abolished by excluding two studies at high risk of bias. After those exclusions, albumin infusion was associated with reduced mortality. The pooled odds ratio was 0.34 with a 95% confidence interval of 0.19 to 0.58 (P < .001). Albumin administration was also accompanied by decreased occurrence of compartment syndrome (pooled odds ratio, 0.19; 95% confidence interval, 0.07-0.50; P < .001). This meta-analysis suggests that albumin can improve outcomes of burn shock resuscitation. However, the scope and quality of current evidence are limited, and additional trials are needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.