Evidence map›Paper›PMID 25426326›Full record

ArticleBiomedical optics express2014

Nanoparticle assisted photothermal deformation of individual neuronal organelles and cells.

V H Romero, Z Kereselidze, W Egido, E A Michaelides, F Santamaria, X G Peralta

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

V H RomeroCentro de Investigaciones en Optica A. C., Leon, Gto, 37150 Mexico ; Universidad de Guadalajara, División de Ciencias, Centro Universitario de Tonalá, Tonalá Jalisco 48525 Mexico ; Equal contribution.
Z KereselidzeDepartment of Physics and Astronomy, University of Texas at San Antonio, San Antonio, TX 78249 USA ; Equal contribution.
W EgidoDepartment of Biology and Neurosciences Institute, University of Texas at San Antonio, San Antonio, TX 78249 USA ; Faculty of Medicine, Universidad Nacional Autonoma de Mexico, Mexico DF 07510 Mexico.
E A MichaelidesDepartment of Biology and Neurosciences Institute, University of Texas at San Antonio, San Antonio, TX 78249 USA.
F SantamariaDepartment of Biology and Neurosciences Institute, University of Texas at San Antonio, San Antonio, TX 78249 USA.
X G PeraltaDepartment of Physics and Astronomy, University of Texas at San Antonio, San Antonio, TX 78249 USA.

Funding

RCMI Center for Interdiscplinary Health Research CIHRG12MD007591 · NIMHD · UNIVERSITY OF TEXAS SAN ANTONIO · PI PERRY, GEORGE · 2012 to 2016
$10.4M
NIMHD NIH HHS G12 MD007591
6 · The paper itself

Abstract

Stimulation of the localized surface plasmon of metallic nanoparticles has been shown to be an effective mechanism to induce photothermal damage in biological tissues. However, few studies have focused on single cell or subcellular ablation. Our results show that, upon incubation, gold nanostars are internalized by neurons of acute mouse cerebellar brain slices, clustering inside or close to the nucleus. By stimulating the nanostars' surface plasmon using a femtosecond laser, we show deformation of single nuclei and single cells. Given its precision and extremely localized effect, this is a promising technique for photothermal therapy in areas sensitive to collateral thermal damage such as the nervous system.

Indexed as

(160.4236) Nanomaterials(170.1020) Ablation of tissue(170.1530) Cell analysis(240.6680) Surface plasmons

Identifiers

PMID25426326
PMCPMC4242034

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.