Evidence map›Paper›PMID 25426308›Full record

ArticleBiomedical optics express2014

Non-invasive transdermal two-dimensional mapping of cutaneous oxygenation with a rapid-drying liquid bandage.

Zongxi Li, Emmanuel Roussakis, Pieter G L Koolen, Ahmed M S Ibrahim, Kuylhee Kim, Lloyd F Rose, Jesse Wu, Alexander J Nichols, Yunjung Baek, Reginald Birngruber and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
7.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 73 citations in OpenAlex.

  1. Article
  2. Article
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  4. Review
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  6. Spray Film-Forming systems as promising topicalSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023
    Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Smart Bandages: The Future of Wound Care.Trends in biotechnology · 2018
    Review
  17. Imaging of oxygen and hypoxia in cell and tissue samples.Cellular and molecular life sciences : CMLS · 2018
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 3 countries.

Zongxi LiWellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, 149 13th Street, Charlestown, Massachusetts 02129, USA.
Emmanuel RoussakisWellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, 149 13th Street, Charlestown, Massachusetts 02129, USA.
Pieter G L KoolenDivision of Plastic Surgery, Harvard Medical School, Beth Israel Deaconess Medical Center, 110 Francis Street Suite 5A, Boston, Massachusetts 02215, USA.
Ahmed M S IbrahimDivision of Plastic Surgery, Harvard Medical School, Beth Israel Deaconess Medical Center, 110 Francis Street Suite 5A, Boston, Massachusetts 02215, USA.
Kuylhee KimDivision of Plastic Surgery, Harvard Medical School, Beth Israel Deaconess Medical Center, 110 Francis Street Suite 5A, Boston, Massachusetts 02215, USA.
Lloyd F RoseDental and Trauma Research Detachment, U.S. Army Institute of Surgical Research, 3698 Chambers Pass, Suite B, JBSA -Fort Sam Houston, Texas 78234-7767, USA.
Jesse WuDental and Trauma Research Detachment, U.S. Army Institute of Surgical Research, 3698 Chambers Pass, Suite B, JBSA -Fort Sam Houston, Texas 78234-7767, USA.
Alexander J NicholsWellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, 149 13th Street, Charlestown, Massachusetts 02129, USA ; Harvard University Program in Biophysics, Building C2 Room 112, 240 Longwood Avenue, Boston, MA 02115, USA ; Harvard-MIT Division of Health Sciences and Technology, 77 Massachusetts Avenue E25-519, Cambridge, MA 02139, USA.
Yunjung BaekWellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, 149 13th Street, Charlestown, Massachusetts 02129, USA ; Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon 305-701, South Korea.
Reginald BirngruberUniversity of Lübeck, Institute of Biomedical Optics, Lübeck, Peter Monnik Weg 4, 23562 Lübeck, Germany.
Gabriela Apiou-SbirleaWellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, 149 13th Street, Charlestown, Massachusetts 02129, USA.
Robina MatyalDepartment of Anesthesia, Critical Care and Pain Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA.
Thomas HuangDepartment of Anesthesia, Critical Care and Pain Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA.
Rodney ChanDental and Trauma Research Detachment, U.S. Army Institute of Surgical Research, 3698 Chambers Pass, Suite B, JBSA -Fort Sam Houston, Texas 78234-7767, USA.
Samuel J LinDivision of Plastic Surgery, Harvard Medical School, Beth Israel Deaconess Medical Center, 110 Francis Street Suite 5A, Boston, Massachusetts 02215, USA.
Conor L EvansWellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, 149 13th Street, Charlestown, Massachusetts 02129, USA ; Harvard University Program in Biophysics, Building C2 Room 112, 240 Longwood Avenue, Boston, MA 02115, USA.
Harvard University · USUnited States Department of the Army · USBeth Israel Deaconess Medical Center · USMassachusetts General Hospital · USHarvard University Press · USKorea Advanced Institute of Science and Technology · KRMassachusetts Institute of Technology · USUniversity of Lübeck · DE

Funding

Imaging and Overcoming Hypoxia-Induced Resistance in Metastatic Ovarian CancerDP2OD007096 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI EVANS, CONOR LEE · 2010 to 2010
$2.7M
NIH HHS DP2 OD007096
6 · The paper itself

Abstract

Oxygen plays an important role in wound healing, as it is essential to biological functions such as cell proliferation, immune responses and collagen synthesis. Poor oxygenation is directly associated with the development of chronic ischemic wounds, which affect more than 6 million people each year in the United States alone at an estimated cost of $25 billion. Knowledge of oxygenation status is also important in the management of burns and skin grafts, as well as in a wide range of skin conditions. Despite the importance of the clinical determination of tissue oxygenation, there is a lack of rapid, user-friendly and quantitative diagnostic tools that allow for non-disruptive, continuous monitoring of oxygen content across large areas of skin and wounds to guide care and therapeutic decisions. In this work, we describe a sensitive, colorimetric, oxygen-sensing paint-on bandage for two-dimensional mapping of tissue oxygenation in skin, burns, and skin grafts. By embedding both an oxygen-sensing porphyrin-dendrimer phosphor and a reference dye in a liquid bandage matrix, we have created a liquid bandage that can be painted onto the skin surface and dries into a thin film that adheres tightly to the skin or wound topology. When captured by a camera-based imaging device, the oxygen-dependent phosphorescence emission of the bandage can be used to quantify and map both the pO2 and oxygen consumption of the underlying tissue. In this proof-of-principle study, we first demonstrate our system on a rat ischemic limb model to show its capabilities in sensing tissue ischemia. It is then tested on both ex vivo and in vivo porcine burn models to monitor the progression of burn injuries. Lastly, the bandage is applied to an in vivo porcine graft model for monitoring the integration of full- and partial-thickness skin grafts.

Indexed as

(160.2540) Fluorescent and luminescent materials(170.2655) Functional monitoring and imaging(170.3880) Medical and biological imaging(170.6510) Spectroscopy, tissue diagnostics

Identifiers

PMID25426308
PMCPMC4242015
OpenAlexW2122659320

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.