Evidence map›Paper›PMID 25426026›Full record

ReviewFrontiers in cellular neuroscience2014

Exosomes/miRNAs as mediating cell-based therapy of stroke.

Hongqi Xin, Yi Li, Michael Chopp

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in cellular neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03437759 (Mesenchymal Stem Cells Derived Exosomes Promote Healing of Large and Refractory Macular Holes), which is not on this map. Cited by 174 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
174citing papers in PubMed, 1 pooled it
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03437759 early_phase1unknown statusnot on this mapstarted 2017, after this paper: background citation

Mesenchymal Stem Cells Derived Exosomes Promote Healing of Large and Refractory Macular Holes

TypeinterventionalSponsorTianjin Medical UniversityRan2017 to 2021Enrolled44ConditionsMacular HolesArmsexosomes derived from mesenchymal stem cells (MSC-Exo)
3 · Its place in the literature

Who cites it

174 citing papers in PubMed, 1 synthesis or guideline pooled it, 311 citations in OpenAlex.

  1. Pooled it
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  16. Extracellular Vesicles Derived from Adipose-Derived Mesenchymal Stem Cells Alleviate Apoptosis and Oxidative Stress of Retinal Pigment Epithelial Cells Through Activation of Nrf2 Signaling Pathway.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2024
    Article
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114 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Hongqi XinDepartment of Neurology, Henry Ford Hospital Detroit, MI, USA.
Yi LiDepartment of Neurology, Henry Ford Hospital Detroit, MI, USA.
Michael ChoppDepartment of Neurology, Henry Ford Hospital Detroit, MI, USA ; Department of Physics, Oakland University Rochester, MI, USA.
Henry Ford Hospital · US

Funding

tPA, white matter and cell therapy for strokeR01NS066041 · NINDS · HENRY FORD HEALTH SYSTEM · PI LIU, ZHONGWU · 2010 to 2014
$1.6M
MSCs Induce Brain Plasticity via tPAR01AG037506 · NIA · HENRY FORD HEALTH SYSTEM · PI CHOPP, MICHAEL · 2011 to 2015
$1.5M
Exosome transfer of miR-133b mediates MSC induced neurological recovery after strR01NS081189 · NINDS · HENRY FORD HEALTH SYSTEM · PI XIN, HONGQI · 2013 to 2016
$1.2M
NIA NIH HHS R01 AG037506NINDS NIH HHS R01 NS066041NINDS NIH HHS R01 NS081189
6 · The paper itself

Abstract

Cell-based therapy, e.g., multipotent mesenchymal stromal cell (MSC) treatment, shows promise for the treatment of various diseases. The strong paracrine capacity of these cells and not their differentiation capacity, is the principal mechanism of therapeutic action. MSCs robustly release exosomes, membrane vesicles (~30-100 nm) originally derived in endosomes as intraluminal vesicles, which contain various molecular constituents including proteins and RNAs from maternal cells. Contained among these constituents, are small non-coding RNA molecules, microRNAs (miRNAs), which play a key role in mediating biological function due to their prominent role in gene regulation. The release as well as the content of the MSC generated exosomes are modified by environmental conditions. Via exosomes, MSCs transfer their therapeutic factors, especially miRNAs, to recipient cells, and therein alter gene expression and thereby promote therapeutic response. The present review focuses on the paracrine mechanism of MSC exosomes, and the regulation and transfer of exosome content, especially the packaging and transfer of miRNAs which enhance tissue repair and functional recovery. Perspectives on the developing role of MSC mediated transfer of exosomes as a therapeutic approach will also be discussed.

Indexed as

bio-information transfercell-based therapyExosomemicroRNAs (miRNAs)multipotent mesenchymal stromal cell (MSC)stroke

Identifiers

PMID25426026
PMCPMC4226157
OpenAlexW2011500268

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.