Evidence map›Paper›PMID 25425970›Full record

ArticleNeoplasia (New York, N.Y.)2014

Up-regulation of FOXM1 by E6 oncoprotein through the MZF1/NKX2-1 axis is required for human papillomavirus-associated tumorigenesis.

Po-Ming Chen, Ya-Wen Cheng, Yao-Chen Wang, Tzu-Chin Wu, Chih-Yi Chen, Huei Lee

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neoplasia (New York, N.Y.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
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  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Viruses in colorectal cancer.Molecular oncology · 2022
    Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. When Viruses Cross Developmental Pathways.Frontiers in cell and developmental biology · 2021
    Review
  18. Article
  19. FOXM1 drives HPV+ HNSCC sensitivity to WEE1 inhibition.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Po-Ming ChenGraduate Institute of Cancer Biology and Drug Discovery, Taipei Medical University, Taipei, Taiwan.
Ya-Wen ChengGraduate Institute of Cancer Biology and Drug Discovery, Taipei Medical University, Taipei, Taiwan.
Yao-Chen WangSchool of Medicine, Chung Shan Medical University, Taichung, Taiwan ; Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan.
Tzu-Chin WuSchool of Medicine, Chung Shan Medical University, Taichung, Taiwan ; Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan.
Chih-Yi ChenDepartment of Surgery, China Medical University Hospital, Taichung, Taiwan.
Huei LeeGraduate Institute of Cancer Biology and Drug Discovery, Taipei Medical University, Taipei, Taiwan.
Taipei Medical University · TWChina Medical University Hospital · TWChung Shan Medical University · TWChung Shan Medical University Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeFoxhead box M1 (FOXM1) expression has been shown to be linked with human papillomavirus (HPV) 16/18-infected cervical cancer. However, the mechanism underlying the induction of FOXM1 in HPV 16/18-infected cancers remains elusive. EXPERIMENTAL

designThe mechanistic actions of FOXM1 induced by the E6/NKX2-1 axis in tumor aggressiveness were elucidated in cellular and animal models. The prognostic value of FOXM1 for overall survival (OS) and relapse-free survival (RFS) in HPV-positive oral and lung cancers was assessed using Kaplan-Meier and Cox regression models.

resultsHerein, FOXM1 expression is upregulated by E6-mediated NKX2-1 in HPV-positive cervical, oral, and lung cancer cells. Induction of FOXM1 by E6 through the MZF1/NKX2-1 axis is responsible for HPV-mediated soft agar growth, invasiveness, and stemness through activating Wnt/β-catenin signaling pathway. In a nude mice model, metastatic lung tumor nodules in HPV 18 E6-positive GNM or HPV 16 E6-positive TL-1-injected nude mice were markedly decreased in both cell types with E6 knockdown, FOXM1 knockdown, or treatment with FOXM1 inhibitor (thiostrepton). Among the four subgroup patients, the worst FOXM1 prognostic value for OS and RFS was observed in HPV 16/18-positive patients with tumors with high-expressing FOXM1.

conclusionsInduction of FOXM1 by E6 oncoprotein through the MZF1/NKX2-1 axis may be responsible for HPV 16/18-mediated tumor progression and poor outcomes in HPV-positive patients.

Indexed as

AlphapapillomavirusAnimalsBlotting, WesternCarcinoma, Non-Small-Cell LungCarcinoma, Squamous CellCell Line, TumorDNA-Binding ProteinsFemaleForkhead Box Protein M1Forkhead Transcription FactorsHost-Pathogen InteractionsHuman papillomavirus 16Human papillomavirus 18HumansKruppel-Like Transcription FactorsLung NeoplasmsDNA-Binding ProteinsE6 protein, Human papillomavirus type 16E6 protein, Human papillomavirus type 18Forkhead Box Protein M1Forkhead Transcription FactorsFOXM1 protein, humanKruppel-Like Transcription FactorsMZF1 protein, humanNkx2-1 protein, mouseNuclear ProteinsOncogene Proteins, ViralRepressor ProteinsThyroid Nuclear Factor 1Transcription Factors

Identifiers

PMID25425970
PMCPMC4240922
OpenAlexW2044769768

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.