ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2015
Diabetes and other comorbidities in breast cancer survival by race/ethnicity: the California Breast Cancer Survivorship Consortium (CBCSC).
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
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48 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- Validation of self-reported comorbidity status of breast cancer patients with medical records: the California Breast Cancer Survivorship Consortium (CBCSC).Cancer causes & control : CCC · 2016Pooled it
- Effect of an anti-inflammatory dietary intervention on quality of life among breast cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Trial
- Quality of life outcomes from a randomized controlled trial of patient navigation in Latina breast cancer survivors.Cancer medicine · 2020Trial
- Impact of a behavioral weight loss intervention on comorbidities in overweight and obese breast cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2016Trial
- Prognostic Value of Different Biological Age Estimation Methods in Breast Cancer Patients: A Population-Based Cohort Study Using NHANES 1999-2020.Health science reports · 2026Article
- Impact of Metformin Use on Clinical and Pathological Outcomes in Breast Cancer Patients With Type 2 Diabetes.Cancer reports (Hoboken, N.J.) · 2026Article
- Prevalence of Cardiovascular Disease and Risk Factors Among Cancer Patients: 5-Year National Inpatient Sample Analysis.JACC. Advances · 2026Article
- The association between pre-existing type 2 diabetes on cancer-related and all-cause mortality among women with breast cancer.Breast cancer research and treatment · 2026Article
- Survival outcomes for neoadjuvant versus adjuvant chemotherapy in early breast cancer patients.The oncologist · 2025Article
- Article
- Urban greenspace and cardiovascular disease comorbidity at breast cancer diagnosis in the US: Regional, racial/ethnic, and socioeconomic variations among older women.Cancer survivorship research & care · 2025Article
- The population-level effects of omitting chemotherapy guided by a 21-gene expression assay in node-positive breast cancer: a simulation modeling study.BMC cancer · 2024Article
- Depression Is Associated with a Higher Risk of Mortality among Breast Cancer Survivors: Results from the National Health and Nutrition Examination Survey-National Death Index Linked Study.Brain sciences · 2024Article
- Article
- A health equity framework to support the next generation of cancer population simulation models.Journal of the National Cancer Institute. Monographs · 2023Article
- Population simulation modeling of disparities in US breast cancer mortality.Journal of the National Cancer Institute. Monographs · 2023Article
- Metformin Therapy and Breast Cancer Incidence in the Ha'il Region.Healthcare (Basel, Switzerland) · 2023Article
- Prevalence, incidence, and mortality rates of breast cancer in Kazakhstan: data from the Unified National Electronic Health System, 2014-2019.Frontiers in public health · 2023Article
- Association of dietary sodium intake with impaired fasting glucose in adult cancer survivors: A population-based cross-sectional study.PloS one · 2023Article
- The Effects of Diabetes and Glycemic Control on Cancer Outcomes in Individuals With Metastatic Breast Cancer.The Journal of clinical endocrinology and metabolism · 2022Article
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16 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe role of comorbidities in survival of patients with breast cancer has not been well studied, particularly in non-white populations.
methodsWe investigated the association of specific comorbidities with mortality in a multiethnic cohort of 8,952 breast cancer cases within the California Breast Cancer Survivorship Consortium (CBCSC), which pooled questionnaire and cancer registry data from five California-based studies. In total, 2,187 deaths (1,122 from breast cancer) were observed through December 31, 2010. Using multivariable Cox proportional hazards regression, we estimated HRs and 95% confidence intervals (CI) for overall and breast cancer-specific mortality associated with previous cancer, diabetes, high blood pressure (HBP), and myocardial infarction.
resultsRisk of breast cancer-specific mortality increased among breast cancer cases with a history of diabetes (HR, 1.48; 95% CI, 1.18-1.87) or myocardial infarction (HR, 1.94; 95% CI, 1.27-2.97). Risk patterns were similar across race/ethnicity (non-Latina white, Latina, African American, and Asian American), body size, menopausal status, and stage at diagnosis. In subgroup analyses, risk of breast cancer-specific mortality was significantly elevated among cases with diabetes who received neither radiotherapy nor chemotherapy (HR, 2.11; 95% CI, 1.32-3.36); no increased risk was observed among those who received both treatments (HR, 1.13; 95% CI, 0.70-1.84; P(interaction) = 0.03). A similar pattern was found for myocardial infarction by radiotherapy and chemotherapy (P(interaction) = 0.09).
conclusionThese results may inform future treatment guidelines for patients with breast cancer with a history of diabetes or myocardial infarction. IMPACT: Given the growing number of breast cancer survivors worldwide, we need to better understand how comorbidities may adversely affect treatment decisions and ultimately outcome.
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