Evidence map›Paper›PMID 25425503›Full record

ArticleJournal of cachexia, sarcopenia and muscle2014

Prevalence, incidence, and clinical impact of sarcopenia: facts, numbers, and epidemiology-update 2014.

John E Morley, Stefan D Anker, Stephan von Haehling

Erratum issued Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cachexia, sarcopenia and muscle, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT04630132 (Renal Ageing-sarcopenia Network), which is not on this map. Cited by 288 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
288citing papers in PubMed, 7 pooled it
25.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04630132 unknown statusnot on this mapstarted 2017, after this paper: background citation

Renal Ageing-sarcopenia Network: a Combined Genetic, Immunological and Psychological Approach to Dissect Frailty

TypeobservationalSponsorIRCCS San RaffaeleRan2017 to 2021Enrolled1,500ConditionsAging, Frailty, Hypertension, CKD
3 · Its place in the literature

Who cites it

288 citing papers in PubMed, 7 syntheses or guidelines pooled it, 595 citations in OpenAlex.

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  7. Effect of sarcopenia on clinical outcomes following digestive carcinoma surgery: a meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019
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  17. [Sarcopenia: diagnosis, clinical implications, and treatment].Innere Medizin (Heidelberg, Germany) · 2026
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228 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

John E MorleyDivisions of Geriatric Medicine and Endocrinology, St. Louis University School of Medicine, 1402 S. Grand Blvd., M238, St. Louis, MO, 63104, USA, morley@slu.edu.
Stefan D Anker
Stephan von Haehling
Charité - Universitätsmedizin Berlin · DESaint Louis University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sarcopenia is now defined as a decline in walking speed or grip strength associated with low muscle mass. Sarcopenia leads to loss of mobility and function, falls, and mortality. Sarcopenia is a major cause of frailty, but either condition can occur without the other being present. Sarcopenia is present in about 5 to 10 % of persons over 65 years of age. It has multiple causes including disease, decreased caloric intake, poor blood flow to muscle, mitochondrial dysfunction, a decline in anabolic hormones, and an increase in proinflammatory cytokines. Basic therapy includes resistance exercise and protein and vitamin D supplementation. There is now a simple screening test available for sarcopenia-SARC-F. All persons 60 years and older should be screened for sarcopenia and treated when appropriate.

Identifiers

PMID25425503
PMCPMC4248415
OpenAlexW2017754801

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.