ArticleJournal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine2014
Ultrasound shear wave elastography helps discriminate low-grade from high-grade bowel wall fibrosis in ex vivo human intestinal specimens.
Article in Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 3 of them syntheses that pooled it.
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Who cites it
49 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Ultrasound Elastography in Inflammatory Bowel Diseases: A Systematic Review of Accuracy Compared with Histopathological Assessment.Journal of Crohn's & colitis · 2022Pooled it
- Pooled it
- Histopathology Scoring Systems of Stenosis Associated With Small Bowel Crohn's Disease: A Systematic Review.Gastroenterology · 2020Pooled it
- Multimodality ultrasound in Crohn's disease strictures.World journal of gastrointestinal pharmacology and therapeutics · 2026Article
- Ustekinumab enhances intestinal stenosis resolution by modulating fibrotic pathways in crohn's disease: a retrospective single-center study with translational analysis.BMC gastroenterology · 2025Article
- Assessing intestinal fibrosis using an endoscopic photoacoustic-ultrasound balloon catheter in rabbits and a human subject.Journal of Crohn's & colitis · 2025Article
- How to use intestinal ultrasonography in patients with Crohn disease: its role in the assessment of disease activity and disease monitoring in the era of the treat-to-target strategy.Ultrasonography (Seoul, Korea) · 2025Article
- Minimally Invasive Bowel Cancer Detection through Vibrating Microrobot-Induced Elastography.Advanced intelligent systems (Weinheim an der Bergstrasse, Germany) · 2025Article
- Elastographic Histogram Analysis as a Non-Invasive Tool for Detecting Early Intestinal Remodeling in Experimental IBD.Journal of clinical medicine · 2025Article
- Ultrasound of the bowel with a focus on IBD: the new best practice.Abdominal radiology (New York) · 2025Review
- Elastography as a Discriminator Between Fibrotic and Inflammatory Strictures in Crohn's Disease: A Dead End or Bright Future in Clinical Decision-Making? Critical Review.Diagnostics (Basel, Switzerland) · 2024Review
- Ultrasound in Pediatric Inflammatory Bowel Disease-A Review of the State of the Art and Future Perspectives.Children (Basel, Switzerland) · 2024Review
- Multimodal dynamic ultrasound approach as predictor of response in patients with Crohn's disease treated with ustekinumab.Therapeutic advances in gastroenterology · 2024Article
- Current and Novel Uses of Intestinal Ultrasound in Inflammatory Bowel Disease.Gastroenterology & hepatology · 2023Article
- The Role of Transabdominal Ultrasound Elastography in Gastrointestinal Non-Liver Diseases: Current Application and Future Prospectives.Diagnostics (Basel, Switzerland) · 2023Review
- How to Evaluate Fibrosis in IBD?Diagnostics (Basel, Switzerland) · 2023Review
- Retrospective Cohort Study of Shear-Wave Elastography and Computed Tomography Enterography in Crohn's Disease.Diagnostics (Basel, Switzerland) · 2023Article
- Intestinal ultrasound as a non-invasive tool to monitor inflammatory bowel disease activity and guide clinical decision making.World journal of gastroenterology · 2023Review
- Ultrasound shear wave elastography in pediatric stricturing small bowel Crohn disease: correlation with histology and second harmonic imaging microscopy.Pediatric radiology · 2023Article
- The Use of Transabdominal Ultrasound in Inflammatory Bowel Disease.Korean journal of radiology · 2022Review
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7 authors.
Funding
Abstract
objectivesTo determine whether bowel wall fibrosis can be detected in freshly resected human intestinal specimens based on ultrasound-derived shear wave speed.
methodsSeventeen intact (>3-cm) bowel segments (15 small and 2 large intestine) from 12 patients with known or suspected inflammatory bowel disease were procured immediately after surgical resection. Ultrasound shear wave elastography of the bowel wall was performed by two methods (Virtual Touch Quantification [VTQ] and Virtual Touch-IQ [VT-IQ]; Siemens Medical Solutions USA, Inc, Mountain View, CA). Eighteen short-axis shear wave speed measurements were acquired from each specimen: 3 from the 9-, 12-, and 3-o'clock locations for each method. Imaging was performed in two areas for specimens greater than 10 cm in length (separated by ≥5 cm). A gastrointestinal pathologist scored correlative histologic slides for inflammation and fibrosis. Differences in mean shear wave speed between bowel segments with low and high inflammation/fibrosis scores were assessed by a Student t test. Receiver operating characteristic curve analysis was performed.
resultsHigh-fibrosis score (n = 11) bowel segments had a significantly greater mean shear wave speed than low-fibrosis score (n = 6) bowel segments (mean ± SD: VTQ, 1.59 ± 0.37 versus 1.18 ± 0.08 m/s; P= .004; VT-IQ, 1.87 ± 0.44 versus 1.50 ± 0.26 m/s; P= .049). There was no significant difference in mean shear wave speed between high-and low-inflammation score bowel segments (P > .05 for both VTQ and VT-IQ). Receiver operating characteristic curves showed areas under the curve of 0.91 (95% confidence interval, 0.67-0.99) for VTQ and 0.77 (95% confidence interval, 0.51-0.94) for VT-IQ in distinguishing low-from high-fibrosis score bowel segments.
conclusionsEx vivo bowel wall shear wave speed measurements increase when transmural intestinal fibrosis is present.
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