Evidence map›Paper›PMID 25425080›Full record

ReviewJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2015

Lactate transport and signaling in the brain: potential therapeutic targets and roles in body-brain interaction.

Linda Hildegard Bergersen

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 137 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
137citing papers in PubMed, 1 pooled it
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

137 citing papers in PubMed, 1 synthesis or guideline pooled it, 238 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Review
  5. Article
  6. Extracellular metabolite production byApplied and environmental microbiology · 2026
    Article
  7. Review
  8. Review
  9. Article
  10. Tanycyte-derived lactate activates astrocytic HCAR1 to modulate glutamatergic signaling and POMC neuron excitability.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  11. Review
  12. Review
  13. Review
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  15. Lactate and cognition: a dual modulator.Frontiers in molecular neuroscience · 2026
    Review
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article

77 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 2 countries.

Linda Hildegard Bergersen1] The Brain and Muscle Energy Group, SN-Lab, Department of Anatomy, Institute of Basic Medical Sciences, Healthy Brain Ageing Centre, University of Oslo, Oslo, Norway [2] Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark [3] Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark [4] The Brain and Muscle Energy Group, Department of Oral Biology, University of Oslo, Oslo, Norway.
University of Oslo · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lactate acts as a 'buffer' between glycolysis and oxidative metabolism. In addition to being exchanged as a fuel by the monocarboxylate transporters (MCTs) between cells and tissues with different glycolytic and oxidative rates, lactate may be a 'volume transmitter' of brain signals. According to some, lactate is a preferred fuel for brain metabolism. Immediately after brain activation, the rate of glycolysis exceeds oxidation, leading to net production of lactate. At physical rest, there is a net efflux of lactate from the brain into the blood stream. But when blood lactate levels rise, such as in physical exercise, there is net influx of lactate from blood to brain, where the lactate is used for energy production and myelin formation. Lactate binds to the lactate receptor GPR81 aka hydroxycarboxylic acid receptor (HCAR1) on brain cells and cerebral blood vessels, and regulates the levels of cAMP. The localization and function of HCAR1 and the three MCTs (MCT1, MCT2, and MCT4) expressed in brain constitute the focus of this review. They are possible targets for new therapeutic drugs and interventions. The author proposes that lactate actions in the brain through MCTs and the lactate receptor underlie part of the favorable effects on the brain resulting from physical exercise.

Indexed as

AnimalsBrainConstitutive Androstane ReceptorExerciseGene Expression RegulationGlycolysisHumansLactic AcidMonocarboxylic Acid TransportersOxidation-ReductionReceptors, Cytoplasmic and NuclearReceptors, G-Protein-CoupledSignal TransductionConstitutive Androstane ReceptorHCAR1 protein, humanLactic AcidMonocarboxylic Acid TransportersReceptors, Cytoplasmic and NuclearReceptors, G-Protein-Coupled

Identifiers

PMID25425080
PMCPMC4426752
OpenAlexW2126862791

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.