ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2015
Increased cerebrovascular sensitivity to endothelin-1 in a rat model of obstructive sleep apnea: a role for endothelin receptor B.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 23 citations in OpenAlex.
- Prevalence and Clinical Correlates of Obstructive Sleep Apnea in Urogynecological Patients with Overactive Bladder.International urogynecology journal · 2026Article
- The physiological role of TRP channels in sleep and circadian rhythm.Journal of cellular and molecular medicine · 2024Review
- Modelling hemodynamics regulation in rats and dogs to facilitate drugs safety risk assessment.Frontiers in pharmacology · 2024Article
- Meta-Analysis: Characteristics of Retinal Vasculature in Obstructive Sleep Apnea Syndrome Humans.Journal of ophthalmology · 2024Article
- Obstructive Sleep Apnea-Induced Hypertension Is Associated With Increased Gut and Neuroinflammation.Journal of the American Heart Association · 2023Article
- Gut microbiota mediate vascular dysfunction in a murine model of sleep apnoea: effect of probiotics.The European respiratory journal · 2023Article
- O‑GlcNAcylation contributes to intermittent hypoxia‑associated vascular dysfunction via modulation of MAPKs but not CaMKII pathways.Molecular medicine reports · 2021Article
- Extracellular Vesicles Derived from Intermittent Hypoxia-Treated Red Blood Cells Impair Endothelial Function Through Regulating eNOS Phosphorylation and ET-1 Expression.Cardiovascular drugs and therapy · 2021Article
- Animal Models of Hypertension: A Scientific Statement From the American Heart Association.Hypertension (Dallas, Tex. : 1979) · 2019Review
- Twik-2Physiological reports · 2019Article
- Fasudil improves endothelial dysfunction in rats exposed to chronic intermittent hypoxia through RhoA/ROCK/NFATc3 pathway.PloS one · 2018Article
- The rat cerebral vasculature exhibits time-of-day-dependent oscillations in circadian clock genes and vascular function that are attenuated following obstructive sleep apnea.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Article
- Obstructive Sleep Apnea-Induced Hypertension: Role of the Gut Microbiota.Current hypertension reports · 2017Review
- Transient receptor potential channel 1/4 reduces subarachnoid hemorrhage-induced early brain injury in rats via calcineurin-mediated NMDAR and NFAT dephosphorylation.Scientific reports · 2016Article
- Self-Reported Sleep Disordered Breathing as Risk Factor for Mortality in the Elderly.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2016Article
- Role of the Gut Microbiome in Obstructive Sleep Apnea-Induced Hypertension.Hypertension (Dallas, Tex. : 1979) · 2016Article
- Pathological effects of obstructive apneas during the sleep cycle in an animal model of cerebral small vessel disease.Hypertension (Dallas, Tex. : 1979) · 2015Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Obstructive sleep apnea (OSA) is associated with cerebrovascular diseases. However, little is known regarding the effects of OSA on the cerebrovascular wall. We tested the hypothesis that OSA augments endothelin-1 (ET-1) constrictions of cerebral arteries. Repeated apneas (30 or 60 per hour) were produced in rats during the sleep cycle (8 hours) by remotely inflating a balloon implanted in the trachea. Four weeks of apneas produced a 23-fold increase in ET-1 sensitivity in isolated and pressurized posterior cerebral arteries (PCAs) compared with PCAs from sham-operated rats (EC50=10(-9.2) mol/L versus 10(-10.6) mol/L; P<0.001). This increased sensitivity was abolished by the ET-B receptor antagonist, BQ-788. Constrictions to the ET-B receptor agonist, IRL-1620, were greater in PCAs from rats after 2 or 4 weeks of apneas compared with that from sham-operated rats (P=0.013). Increased IRL-1620 constrictions in PCAs from OSA rats were normalized with the transient receptor potential channel (TRPC) blocker, SKF96365, or the Rho kinase (ROCK) inhibitor, Y27632. These data show that OSA increases the sensitivity of PCAs to ET-1 through enhanced ET-B activity, and enhanced activity of TRPCs and ROCK. We conclude that enhanced ET-1 signaling is part of a pathologic mechanism associated with adverse cerebrovascular outcomes of OSA.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.