Evidence map›Paper›PMID 25424935›Full record

ReviewHuman vaccines & immunotherapeutics2014

Oral immunotherapy for the treatment of food allergy.

Philippe Begin, R Sharon Chinthrajah, Kari C Nadeau

Abstract readReview
In one paragraph

Review in Human vaccines & immunotherapeutics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Eight tips for the implementation of the first licenced peanut allergy oral immunotherapy into clinical practice.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2022
    Article
  6. Peanut allergy: Beyond the oral immunotherapy plateau.Clinical and translational allergy · 2021
    Review
  7. Review
  8. Article
  9. Review
  10. Cashew Nut Allergy: Clinical Relevance and Allergen Characterisation.Clinical reviews in allergy & immunology · 2019
    Review
  11. Review
  12. Immunotherapy for cow's milk allergy.Human vaccines & immunotherapeutics · 2017
    Review
  13. Update on oral immunotherapy for egg allergy.Human vaccines & immunotherapeutics · 2017
    Review
  14. Article
  15. Molecular and cellular mechanisms of food allergy and food tolerance.The Journal of allergy and clinical immunology · 2016
    Review
  16. Review
  17. Immune mechanisms of sublingual immunotherapy.Current allergy and asthma reports · 2014
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Philippe Begina Stanford University; Stanford, CA USA.
R Sharon Chinthrajah
Kari C Nadeau

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oral immunotherapy (OIT) is an emerging new therapy for food allergy. With multiple small exploratory trials and some large randomized-controlled phase 2 trials recently published and under way, there is a clear progress and interest toward making this a treatment option for patients suffering from food allergies. However, there are still many questions to be answered and parameters to fine-tune before OIT becomes an accepted option outside of the research setting. This review covers the main milestones in the development of OIT for food allergy and further discusses important specific issues that will have direct impact on its clinical application. More specifically, previous publications showing evidence for the induction of tolerance are specifically reviewed and varying safety, tolerability and efficacy parameters from previous reports are also discussed.

Indexed as

Administration, OralClinical Trials as TopicFood HypersensitivityHumansImmunologic FactorsImmunotherapyTreatment OutcomeImmunologic FactorsefficacyFood allergyomalizumabOral immunotherapy (OIT)rushsafetytolerance

Identifiers

PMID25424935
PMCPMC4896783

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.